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有慧, 牛富生, 王剑, 郑福玲, 孟春玲, 张振馨, 倪道凤, 冯逢. 高分辨磁共振成像用于阿尔茨海默病嗅球体积测量[J]. 协和医学杂志, 2011, 2(3): 209-212. DOI: 10.3969/j.issn.1674-9081.2011.03.004
引用本文: 有慧, 牛富生, 王剑, 郑福玲, 孟春玲, 张振馨, 倪道凤, 冯逢. 高分辨磁共振成像用于阿尔茨海默病嗅球体积测量[J]. 协和医学杂志, 2011, 2(3): 209-212. DOI: 10.3969/j.issn.1674-9081.2011.03.004
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Hui YOU, Fu-sheng NIU, Jian WANG, Fu-ling ZHENG, Chun-ling MENG, Zhen-xin ZHANG, Dao-feng NI, Feng FENG. Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(3): 209-212. DOI: 10.3969/j.issn.1674-9081.2011.03.004
Citation: Hui YOU, Fu-sheng NIU, Jian WANG, Fu-ling ZHENG, Chun-ling MENG, Zhen-xin ZHANG, Dao-feng NI, Feng FENG. Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(3): 209-212. DOI: 10.3969/j.issn.1674-9081.2011.03.004
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高分辨磁共振成像用于阿尔茨海默病嗅球体积测量

Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease

    摘要
  • 摘要:
      目的  评价阿尔茨海默病(Alzheimer disease, AD)患者嗅球体积变化。
      方法  对14例AD患者及25名正常老年志愿者行高分辨嗅球磁共振成像(magnetic resonance imaging, MRI), 测量嗅球体积。
      结果  AD患者较大侧嗅球体积为(32.2±7.7)mm3, 小于正常老年志愿者的(40.6±6.6)mm3(P=0.002)。AD患者嗅球体积与简易精神状态检查量表(mini-mental state examination, MMSE)评分无明显相关性(P=0.205)。
      结论  AD患者嗅球体积减小, 符合神经病理学表现。MRI可以发现AD患者嗅球体积改变, 可能为AD诊断提供帮助。

     

    Abstract:
      Objective  To explore the change of olfactory bulb (OB) volume in patients with Alzheimer disease (AD) and assess the value of high-resolution magnetic resonance imaging (MRI) in measuring OB volume.
      Methods  Fourteen AD patients and 25 normal aging volunteers (control group) underwent high-resolution MRI imaging of OB and the OB volume was measured.
      Results  The OB volume in AD patients(32.2±7.7) mm3 was significantly smaller than that in control group(40.6±6.6) mm3(P=0.002). The OB volume in AD patients didn't correlate significantly with their mini-mental state examination (MMSE) scores (P=0.205).
      Conclusions  AD patients show more prominent OB atrophy than normal aging volunteers do, which is in agreement with the pathological findings. High-resolution MRI is valuable in identifying the change of OB volume and therefore might be beneficial for AD diagnosis.

     

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