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高分辨磁共振成像用于阿尔茨海默病嗅球体积测量

有慧 牛富生 王剑 郑福玲 孟春玲 张振馨 倪道凤 冯逢

有慧, 牛富生, 王剑, 郑福玲, 孟春玲, 张振馨, 倪道凤, 冯逢. 高分辨磁共振成像用于阿尔茨海默病嗅球体积测量[J]. 协和医学杂志, 2011, 2(3): 209-212. doi: 10.3969/j.issn.1674-9081.2011.03.004
引用本文: 有慧, 牛富生, 王剑, 郑福玲, 孟春玲, 张振馨, 倪道凤, 冯逢. 高分辨磁共振成像用于阿尔茨海默病嗅球体积测量[J]. 协和医学杂志, 2011, 2(3): 209-212. doi: 10.3969/j.issn.1674-9081.2011.03.004
Hui YOU, Fu-sheng NIU, Jian WANG, Fu-ling ZHENG, Chun-ling MENG, Zhen-xin ZHANG, Dao-feng NI, Feng FENG. Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(3): 209-212. doi: 10.3969/j.issn.1674-9081.2011.03.004
Citation: Hui YOU, Fu-sheng NIU, Jian WANG, Fu-ling ZHENG, Chun-ling MENG, Zhen-xin ZHANG, Dao-feng NI, Feng FENG. Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(3): 209-212. doi: 10.3969/j.issn.1674-9081.2011.03.004

高分辨磁共振成像用于阿尔茨海默病嗅球体积测量

doi: 10.3969/j.issn.1674-9081.2011.03.004
详细信息
    通讯作者:

    有慧 电话:010-65297440, E-mail:youhuimr77@yahoo.com.cn

  • 中图分类号: R445.2;R749.1+6

Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease

More Information
  • 摘要:   目的  评价阿尔茨海默病(Alzheimer disease, AD)患者嗅球体积变化。  方法  对14例AD患者及25名正常老年志愿者行高分辨嗅球磁共振成像(magnetic resonance imaging, MRI), 测量嗅球体积。  结果  AD患者较大侧嗅球体积为(32.2±7.7)mm3, 小于正常老年志愿者的(40.6±6.6)mm3(P=0.002)。AD患者嗅球体积与简易精神状态检查量表(mini-mental state examination, MMSE)评分无明显相关性(P=0.205)。  结论  AD患者嗅球体积减小, 符合神经病理学表现。MRI可以发现AD患者嗅球体积改变, 可能为AD诊断提供帮助。
  • 表  1  AD患者及正常老年志愿者嗅球体积(mm3)

    组别 右侧嗅球体积 左侧嗅球体积 较大侧嗅球体积
    正常志愿者 39. 7 ± 6. 5 37. 2 ± 7. 9 40. 6 ± 6. 6
    AD患者 2. 1 ± 7. 8* 26. 1 ± 10. 3** 32. 2 ± 7. 7***
    AD患者与正常志愿者比较,独立样本t检验,* t = - 3. 022,P = 0. 005; **t = - 3. 523,P = 0. 001; ***t = - 3. 344,P = 0. 002
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出版历程
  • 收稿日期:  2011-04-25
  • 刊出日期:  2011-07-30

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