Abstract: Pancreatic cancer, one of the most lethal cancers in the world, its incidence and mortality are increasing year by year, and the overall prognosis of patients is very poor. Early detection and effective treatment are crucial for improving the prognosis and survival rates of pancreatic cancer patients. Different from traditional imaging, emerging molecular imaging can visualize the abnormalities at the molecular or cellular level in the process of tumor development. At present, multi-modal molecular imaging that integrates multiple imaging methods to achieve complementary advantages and multi-functional nanoplatforms with integrated diagnosis and treatment functions have become research hotspots in the field of molecular imaging. A variety of magnetic-optical multimodality molecular imaging probes and their derived multi-functional nanoplatforms have made remarkable progress in preclinical research, providing new ideas for early detection, accurate treatment and efficacy evaluation of pancreatic cancer.