Abstract: Alzheimer's disease(AD) is the most common neurodegenerative disease, has shown a trend of younger, most patients once onset, cognitive function will show a progressive decline, to the society and the family brings a heavy burden. Studies have shown that fibroblast growth factor (FGF) can be involved in the pathogenesis of AD through multiple mechanisms.In recent years, the research of FGF in AD animal models has made a breakthrough. This article reviews the mechanism of FGF in AD, providing new ideas for elucidating the pathogenesis and early diagnosis of AD.