Abstract: To standardize the use of antibiotics for surgical prophylaxis, ensure patient safety, improve medical quality, and combat bacterial resistance, the editorial committee at Peking Union Medical College Hospital for the management of antibiotics for surgical prophylaxis has formed management practice of perioperative prophylactic use of antibiotics. The management practice, based on the Guideline Principles for the Clinical Application of Antimicrobial Drugs (2015 edition) issued by the National Health Commission of People's Republic of China, also reviews the authoritative literature at home and abroad and combines with our hospital's antimicrobial drugs catalog and characteristics of bacterial resistance, with the hope of promoting the rational use of antibiotics.