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压力感受性反射在疼痛调控中的机制及临床应用

崔雀玄 车璐 许力

崔雀玄, 车璐, 许力. 压力感受性反射在疼痛调控中的机制及临床应用[J]. 协和医学杂志, 2024, 15(2): 258-264. doi: 10.12290/xhyxzz.2023-0552
引用本文: 崔雀玄, 车璐, 许力. 压力感受性反射在疼痛调控中的机制及临床应用[J]. 协和医学杂志, 2024, 15(2): 258-264. doi: 10.12290/xhyxzz.2023-0552
CUI Quexuan, CHE Lu, XU Li. Baroreflex in Pain Regulation: Pathogenic Mechanism and Clinical Application[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(2): 258-264. doi: 10.12290/xhyxzz.2023-0552
Citation: CUI Quexuan, CHE Lu, XU Li. Baroreflex in Pain Regulation: Pathogenic Mechanism and Clinical Application[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(2): 258-264. doi: 10.12290/xhyxzz.2023-0552

压力感受性反射在疼痛调控中的机制及临床应用

doi: 10.12290/xhyxzz.2023-0552
基金项目: 

中央高水平医院临床科研专项 2022-PUMCH-B-119

详细信息
    通讯作者:

    许力, E-mail:pumchxuli@163.com

  • 中图分类号: R614;R364

Baroreflex in Pain Regulation: Pathogenic Mechanism and Clinical Application

Funds: 

National High Level Hospital Clinical Research Funding 2022-PUMCH-B-119

More Information
  • 摘要: 压力感受性反射是自主神经系统维持心血管稳态的重要机制,其与疼痛调控亦存在密切关系。压力反射敏感性(baroreflex sensitivity, BRS)是定量评估压力感受性反射功能的指标,BRS下降与疼痛敏感性上升存在相关性,在疼痛风险预测、治疗效果评估中应用前景广阔。迷走神经刺激能够激活压力感受性反射,近年来在急慢性疼痛患者中得到了广泛应用。本文就压力感受性反射在疼痛调控中的机制和临床应用进行概述,以期为探索调节压力感受性反射功能的疼痛治疗手段提供新思路。
    作者贡献:崔雀玄负责文献检索、论文撰写;车璐负责文献检索、论文修订及图片绘制;许力提出选题思路、修订及审校论文。
    利益冲突:所有作者均声明不存在利益冲突
  • 图  1  压力感受性反射通路及影响疼痛的机制

    NST(nucleus tractus solitarius):孤束核;CVLM(caudal ventrolateral medulla):延髓腹外侧尾端区;RVLM(rostral ventrolateral medulla):延髓头端腹外侧区;CNS(central nervous system):中枢神经系统;BRS(baroreflex sensitivity):压力反射敏感性

    Figure  1.  Pathway of baroreceptor reflex and its mechanism of affecting pain

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出版历程
  • 收稿日期:  2023-11-20
  • 录用日期:  2023-12-18
  • 网络出版日期:  2023-12-22
  • 刊出日期:  2024-03-30

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