Abstract: Objective To investigate the expression and significance of cell surface receptor signaling lymphocyte activation molecule receptor 7 (SLAMF7) in normal intestinal tissues and intestinal inflammatory tissues of mice. Methods Five C57BL/6J wild-type male mice aged 8-10 weeks were taken and fed normally. Lamina propria lymphocytes (LPLs) and intestinal epithelial cells (IECs) were extracted, and total cell RNA was extracted by Trizol reagent. The mRNA expression of SLAMF7 in cells was detected by reverse transcription polymerase chain reaction (RT-PCR) and real-time fluorescent quantitative polymerase chain reaction (RT-qPCR). Ten C57BL/6J wild-type male mice aged 8-10 weeks were randomly divided into control group (n=5) and model group (n=5). The control group was fed with normal drinking water for 5 days, the model group was fed with 2.5% dextran sodium sulfate (DSS) drinking water for 5 days to establish a model of ulcerative colitis(UC), and the mice in both groups were killed on the 5th day. Flow cytometry was used to detect the expression of SLAMF7 in immune cell subpopulations in the control group and the model group. Results Compared with colonic IECs, the expression of SLAMF7 was higher in colonic LPLs (P=0.017). After DSS induced enteritis, the expression of SLAMF7 was up-regulated in neutrophils (P=0.001), but had no significant changes in CD4+T cells, CD8⁺T cells, B cells, macrophages and conventional dendritic cell (all P＞0.05). Conclusion SLAMF7 may play a certain role in the occurrence and development of UC through neutrophilrelated pathways.