邮件订阅 RSS

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

阻塞性睡眠呼吸暂停诱导肠道菌群失调与缺血性脑卒中：机制与研究进展

刘苗苗,  岳红梅,  李雅亭,  许金回,  武兴东,  朱浩斌

downloadPDF
文章导航 > 协和医学杂志  > 2024 >  15(2): 382-386
刘苗苗, 岳红梅, 李雅亭, 许金回, 武兴东, 朱浩斌. 阻塞性睡眠呼吸暂停诱导肠道菌群失调与缺血性脑卒中：机制与研究进展[J]. 协和医学杂志, 2024, 15(2): 382-386. doi: 10.12290/xhyxzz.2023-0452
引用本文: 刘苗苗, 岳红梅, 李雅亭, 许金回, 武兴东, 朱浩斌. 阻塞性睡眠呼吸暂停诱导肠道菌群失调与缺血性脑卒中：机制与研究进展[J]. 协和医学杂志, 2024, 15(2): 382-386. doi: 10.12290/xhyxzz.2023-0452
shu
LIU Miaomiao, YUE Hongmei, LI Yating, XU Jinhui, WU Xingdong, ZHU Haobin. Obstructive Sleep Apnea-induced Gut Dysbiosis and Ischaemic Stroke: Mechanism and Research Progress[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(2): 382-386. doi: 10.12290/xhyxzz.2023-0452
Citation: LIU Miaomiao, YUE Hongmei, LI Yating, XU Jinhui, WU Xingdong, ZHU Haobin. Obstructive Sleep Apnea-induced Gut Dysbiosis and Ischaemic Stroke: Mechanism and Research Progress[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(2): 382-386. doi: 10.12290/xhyxzz.2023-0452
shu

阻塞性睡眠呼吸暂停诱导肠道菌群失调与缺血性脑卒中：机制与研究进展

doi: 10.12290/xhyxzz.2023-0452
  • 1.

    兰州大学第一临床医学院，兰州 730000

  • 2.

    兰州大学第一医院呼吸与危重症医学科, 兰州 730000

基金项目: 

甘肃省科技计划 22ZD1FA00A

详细信息
    通讯作者:

    岳红梅, E-mail: yuehongmei18@sina.com

  • 中图分类号: R743;R543;R562

Obstructive Sleep Apnea-induced Gut Dysbiosis and Ischaemic Stroke: Mechanism and Research Progress

  • 1.

    The First Clinical Medical School, Lanzhou University, Lanzhou 730000, China

  • 2.

    Department of Pulmonary and Critical Care Medicine, the First Hospital of Lanzhou University, Lanzhou 730000, China

Funds: 

Science and Technology Project of Gansu Province 22ZD1FA00A

More Information

    摘要
  • 摘要: 缺血性脑卒中作为一种高发病率、高死亡率、高致残率、高复发率的脑血管疾病，是导致我国中老年人残疾和死亡的重要原因。因此，识别与缺血性脑卒中相关危险因素并进行有效预防至关重要。有研究表明，阻塞性睡眠呼吸暂停是缺血性脑卒中发生的独立危险因素，但具体机制尚未明确。随着新一代测序技术的发展，研究发现阻塞性睡眠呼吸暂停可引起肠道菌群改变，而肠道菌群可能与缺血性脑卒中密切相关。因此，本文就阻塞性睡眠呼吸暂停诱导肠道菌群失调与缺血性脑卒中的相关机制进行综述，以期为阐明阻塞性睡眠呼吸暂停引起缺血性脑卒中的潜在病理机制提供依据。
    Abstract: Ischemic stroke, a cerebrovascular disease with high incidence, high mortality, high disability rate and high recurrence rate, is an important cause of death and disability of middle-aged and elderly people in China, and imposes a huge burden to society and families. Therefore, it is essential to identify the risk factors associated with ischemic stroke and effectively prevent them. Studies have shown that obstructive sleep apnea is an independent risk factor for ischemic stroke. However, the exact pathological mechanism of their association has not been clarified. With the development of next-generation sequencing technology, more and more studies have focused on intestinal microbiota. They have found that obstructive sleep apnea can cause intestinal microbiota changes, and intestinal microbiota may be closely related to ischemic stroke. Therefore, this paper attempts to investigate the relationship between intestinal flora and ischemic stroke, so as to reveal the potential pathological mechanism of ischemic stroke caused by obstructive sleep apnea.
    作者贡献：刘苗苗负责论文撰写；岳红梅负责选题设计及论文修订；李雅亭、许金回负责文献收集；武兴东、朱浩斌负责论文修订。
    利益冲突：所有作者均声明不存在利益冲突
    • HTML全文
    • 参考文献(33)
  • [1] Pan Z J, Ma T P, Zeng Q H, et al. People's knowledge, attitudes, practice, and healthcare education demand regard-ing OSA: a cross-sectional study among Chinese general populations[J]. Front Public Health, 2023, 11: 1128334. doi:  10.3389/fpubh.2023.1128334
    [2] Javaheri S, Peker Y, Yaggi H K, et al. Obstructive sleep apnea and stroke: the mechanisms, the randomized trials, and the road ahead[J]. Sleep Med Rev, 2022, 61: 101568. doi:  10.1016/j.smrv.2021.101568
    [3] Sanchez O, Adra N, Chuprevich S, et al. Screening for OSA in stroke patients: the role of a sleep educator[J]. Sleep Med, 2022, 100: 196-197. doi:  10.1016/j.sleep.2022.08.024
    [4] Okubo H, Nakatsu Y, Kushiyama A, et al. Gut microbiota as a therapeutic target for metabolic disorders[J]. Curr Med Chem, 2018, 25(9): 984-1001. doi:  10.2174/0929867324666171009121702
    [5] Berding K, Vlckova K, Marx W, et al. Diet and the microbiota-gut-brain axis: sowing the seeds of good mental health[J]. Adv Nutr, 2021, 12(4): 1239-1285. doi:  10.1093/advances/nmaa181
    [6] Badran M, Mashaqi S, Gozal D. The gut microbiome as a target for adjuvant therapy in obstructive sleep apnea[J]. Expert Opin Ther Targets, 2020, 24(12): 1263-1282. doi:  10.1080/14728222.2020.1841749
    [7] Fava F, Rizzetto L, Tuohy K M. Gut microbiota and health: connecting actors across the metabolic system[J]. Proc Nutr Soc, 2019, 78(2): 177-188. doi:  10.1017/S0029665118002719
    [8] Cai Y, Juszczak H M, Cope E K, et al. The microbiome in obstructive sleep apnea[J]. Sleep, 2021, 44(8): zsab061. doi:  10.1093/sleep/zsab061
    [9] Poroyko V A, Carreras A, Khalyfa A, et al. Chronic sleep disruption alters gut microbiota, induces systemic and adipose tissue inflammation and insulin resistance in mice[J]. Sci Rep, 2016, 6: 35405. doi:  10.1038/srep35405
    [10] Xue J, Allaband C, Zhou D, et al. Influence of intermittent hypoxia/hypercapnia on atherosclerosis, gut microbiome, and metabolome[J]. Front Physiol, 2021, 12: 663950. doi:  10.3389/fphys.2021.663950
    [11] Zeng J S, Yang K L, Nie H F, et al. The mechanism of intestinal microbiota regulating immunity and inflammation in ischemic stroke and the role of natural botanical active ingredients in regulating intestinal microbiota: a review[J]. Biomed Pharmacother, 2023, 157: 114026. doi:  10.1016/j.biopha.2022.114026
    [12] Hu W J, Kong X Y, Wang H, et al. Ischemic stroke and intestinal flora: an insight into brain-gut axis[J]. Eur J Med Res, 2022, 27(1): 73. doi:  10.1186/s40001-022-00691-2
    [13] Sharma V, Sharma V, Shahjouei S, et al. At the intersection of gut microbiome and stroke: a systematic review of the literature[J]. Front Neurol, 2021, 12: 729399. doi:  10.3389/fneur.2021.729399
    [14] Nam H S. Gut microbiota and ischemic stroke: the role of trimethylamine N-oxide[J]. J Stroke, 2019, 21(2): 151-159. doi:  10.5853/jos.2019.00472
    [15] Zhu W F, Gregory J C, Org E, et al. Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk[J]. Cell, 2016, 165(1): 111-124. doi:  10.1016/j.cell.2016.02.011
    [16] El Hage R, Al-Arawe N, Hinterseher I. The role of the gut microbiome and trimethylamine oxide in atherosclerosis and age-related disease[J]. Int J Mol Sci, 2023, 24(3): 2399. doi:  10.3390/ijms24032399
    [17] Zhang J L, Wang L K, Cai J L, et al. Gut microbial metabolite TMAO portends prognosis in acute ischemic stroke[J]. J Neuroimmunol, 2021, 354: 577526. doi:  10.1016/j.jneuroim.2021.577526
    [18] Mirzaei R, Bouzari B, Hosseini-Fard S R, et al. Role of microbiota-derived short-chain fatty acids in nervous system disorders[J]. Biomed Pharmacother, 2021, 139: 111661. doi:  10.1016/j.biopha.2021.111661
    [19] Tan C H, Wu Q H, Wang H D, et al. Dysbiosis of gut microbiota and short-chain fatty acids in acute ischemic stroke and the subsequent risk for poor functional outcomes[J]. JPEN J Parenter Enteral Nutr, 2021, 45(3): 518-529. doi:  10.1002/jpen.1861
    [20] Lee J, D'Aigle J, Atadja L, et al. Gut microbiota-derived short-chain fatty acids promote poststroke recovery in aged mice[J]. Circ Res, 2020, 127(4): 453-465. doi:  10.1161/CIRCRESAHA.119.316448
    [21] Li P, Dong Z Y, Chen W H, et al. Causal relations between obstructive sleep apnea and stroke: a mendelian randomiza-tion study[J]. Nat Sci Sleep, 2023, 15: 257-266. doi:  10.2147/NSS.S398544
    [22] Zhao L N, Yang L J, Guo Y Y, et al. New insights into stroke prevention and treatment: gut microbiome[J]. Cell Mol Neurobiol, 2022, 42(2): 455-472. doi:  10.1007/s10571-021-01047-w
    [23] Xue J, Zhou D, Poulsen O, et al. Intermittent hypoxia and hypercapnia accelerate atherosclerosis, partially via trimethylamine-oxide[J]. Am J Respir Cell Mol Biol, 2017, 57(5): 581-588. doi:  10.1165/rcmb.2017-0086OC
    [24] Wang Z N, Klipfell E, Bennett B J, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease[J]. Nature, 2011, 472(7341): 57-63. doi:  10.1038/nature09922
    [25] Ding L, Chang M R, Guo Y, et al. Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism[J]. Lipids Health Dis, 2018, 17(1): 286. doi:  10.1186/s12944-018-0939-6
    [26] Xia W Y, Huang Y H, Peng B, et al. Relationship between obstructive sleep apnoea syndrome and essential hypertension: a dose-response meta-analysis[J]. Sleep Med, 2018, 47: 11-18. doi:  10.1016/j.sleep.2018.03.016
    [27] Munir S S, Sert Kuniyoshi F H, Singh P, et al. Is the gut microbiome implicated in the excess risk of hypertension associated with obstructive sleep apnea? A contemporary review[J]. Antioxidants (Basel), 2023, 12(4): 866. doi:  10.3390/antiox12040866
    [28] Durgan D J. Obstructive sleep apnea-induced hypertension: role of the gut microbiota[J]. Curr Hypertens Rep, 2017, 19(4): 35.
    [29] Jiao Y, Li W X, Zhang Q Y, et al. Gut microbiota and hypertension: a bibliometric analysis of recent research (2014—2023)[J]. Front Nutr, 2023, 10: 1253803. doi:  10.3389/fnut.2023.1253803
    [30] Liu J, Li T X, Wu H, et al. Lactobacillus rhamnosus GG strain mitigated the development of obstructive sleep apnea-induced hypertension in a high salt diet via regulating TMAO level and CD4+ T cell induced-type Ⅰ inflammation[J]. Biomed Pharmacother, 2019, 112: 108580.
    [31] 伍娟, 杨眉峰, 楼莹, 等. 肠道微生物与阻塞性睡眠呼吸暂停低通气综合征及其并发症的相关性研究进展[J]. 江西中医药大学学报, 2019, 31(6): 117-121. https://www.cnki.com.cn/Article/CJFDTOTAL-XYXB201906036.htm

    Wu J, Yang M F, Lou Y, et al. Research progress of correlation between intestinal microorganism and OSAHS and its complications[J]. J Jiangxi Univ Tradit Chin Med, 2019, 31(6): 117-121. https://www.cnki.com.cn/Article/CJFDTOTAL-XYXB201906036.htm
    [32] Khalyfa A, Ericsson A, Qiao Z H, et al. Circulating exosomes and gut microbiome induced insulin resistance in mice exposed to intermittent hypoxia: effects of physical activity[J]. EBioMedicine, 2021, 64: 103208.
    [33] Pack A I. Gut microbiome: role in insulin resistance in obstructive sleep apnea[J]. EBioMedicine, 2021, 65: 103278.
    • 相关文章
    • 施引文献
  • 资源附件(0)
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  105
  • HTML全文浏览量:  37
  • PDF下载量:  21
  • 被引次数: 0
出版历程
  • 收稿日期:  2023-09-25
  • 录用日期:  2023-11-20
  • 刊出日期:  2024-03-30

目录

    /

    返回文章
    返回
    友情链接: 国家卫生健康委员会 北京协和医院 中国医学科学院 学术不端检测系统 国际知识资源总库 中国知网 术语在线 中国全科医学
    地址：北京市东城区帅府园1号 北京协和医院老楼7号楼
    3层302室 《协和医学杂志》编辑部
    电话：010-69154261/4262
    E - mail：medj@pumch.cn
    mjpumch@126.com
    期刊网站版权所有：《协和医学杂志》编辑部
    京ICP备 11002662

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计

    x 关闭 永久关闭

    【温馨提醒】近日，《协和医学杂志》编辑部接到作者反映，有多名不法人员冒充期刊编辑发送见刊通知，鼓动作者添加微信，从而骗取版面费的行为。特提醒您，本刊与作者联系的方式均为邮件通知或电话，稿件进度通知邮箱为：mjpumch@126.com，编辑部电话为：010-69154261，请提高警惕，谨防上当受骗！如有任何疑问，请致电编辑部核实。谢谢！