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感染在自身免疫性疾病中的作用机制

程琳琳 李詹 李永哲

程琳琳, 李詹, 李永哲. 感染在自身免疫性疾病中的作用机制[J]. 协和医学杂志, 2023, 14(5): 925-931. doi: 10.12290/xhyxzz.2023-0268
引用本文: 程琳琳, 李詹, 李永哲. 感染在自身免疫性疾病中的作用机制[J]. 协和医学杂志, 2023, 14(5): 925-931. doi: 10.12290/xhyxzz.2023-0268
CHENG Linlin, LI Zhan, LI Yongzhe. Research Progress on the Mechanism of Infection in Autoimmune Diseases[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 925-931. doi: 10.12290/xhyxzz.2023-0268
Citation: CHENG Linlin, LI Zhan, LI Yongzhe. Research Progress on the Mechanism of Infection in Autoimmune Diseases[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 925-931. doi: 10.12290/xhyxzz.2023-0268

感染在自身免疫性疾病中的作用机制

doi: 10.12290/xhyxzz.2023-0268
基金项目: 

国家重点研发计划 2018YFE0207300

中央高水平医院临床科研专项 2022-PUMCH-B-124

北京市自然科学基金 M23008

北京市自然科学基金 7234383

中国博士后科学基金 2023T160060

详细信息
    通讯作者:

    李永哲, E-mail:yongzhelipumch@126.com

    程琳琳、李詹对本文同等贡献

    程琳琳、李詹对本文同等贡献

  • 中图分类号: R446.5;R51;R593

Research Progress on the Mechanism of Infection in Autoimmune Diseases

Funds: 

National Key Research and Development Program of China 2018YFE0207300

National High-level Hospital Clinical Research Funding 2022-PUMCH-B-124

Beijing Municipal Natural Science Foundation Project M23008

Beijing Municipal Natural Science Foundation Project 7234383

China Postdoctoral Science Foundation 2023T160060

More Information
  • 摘要: 自身免疫性疾病(autoimmune disease, AID)发病机制复杂。近年来,越来越多的证据表明,感染在驱动具有潜在遗传背景的AID的发生和进展中起关键作用,这为临床重新审视AID的诱因及可能机制提供了更广阔和新颖的视角。本文通过总结病原微生物与自身免疫/AID相关性的最新研究进展,旨在从病原学角度探讨常见AID的病因和发病机制,以期通过整合现有证据,加深对AID发病机制的认识,为疾病预防和临床诊疗提供有价值的见解。
    作者贡献:程琳琳、李詹负责查阅文献、撰写及修订论文;李永哲负责修订论文、终审及校对。
    利益冲突:所有作者均声明不存在利益冲突
  • 表  1  自身免疫性疾病及相关病原微生物

    疾病分类 相关病原微生物
    器官特异性自身免疫性疾病
      1型糖尿病[3] 肠道病毒/菌群,巨细胞病毒
      原发性胆汁性胆管炎[4] 大肠埃希菌,幽门螺杆菌
      多发性硬化症[5] EB病毒,巨细胞病毒,人疱疹病毒6型,水痘-带状疱疹病毒
    系统性自身免疫性疾病
      系统性红斑狼疮[6] EB病毒,水痘带状疱疹病毒,人乳头状瘤病毒,轮状病毒,肠道病毒,人内源性逆转录病毒,登革热病毒,肠道菌群,弓形虫
      类风湿关节炎[7] EB病毒,巨细胞病毒,人内源性逆转录病毒,人乳头瘤病毒,胃肠道/口腔菌群
      白塞病[8] 链球菌,结核分枝杆菌,幽门螺杆菌,肠道/口腔菌群,疱疹病毒科
      系统性硬化症[9] EB病毒,细小病毒B19,幽门螺杆菌,巨细胞病毒,人疱疹病毒6型,逆转录病毒
      干燥综合征[10] EB病毒,细小病毒B19,丙型肝炎病毒,人疱疹病毒6型,巨细胞病毒,人嗜T淋巴球病毒1型,共生菌
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  • 收稿日期:  2023-06-05
  • 录用日期:  2023-07-17
  • 网络出版日期:  2023-08-02
  • 刊出日期:  2023-09-30

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