感染在自身免疫性疾病中的作用机制

程琳琳; 李詹; 李永哲

doi:10.12290/xhyxzz.2023-0268

感染在自身免疫性疾病中的作用机制

doi: 10.12290/xhyxzz.2023-0268

程琳琳^1,2,
李詹^1,2,
李永哲^1,2, ,

1 中国医学科学院北京协和医院检验科, 北京 100730;
2 中国医学科学院北京协和医院疑难重症及罕见病国家重点实验室, 北京 100730

基金项目:

国家重点研发计划（2018YFE0207300）；中央高水平医院临床科研业务费项目（2022-PUMCH-B-124）；北京市自然科学基金（M23008，7234383）

详细信息

通讯作者:
李永哲,E-mail:yongzhelipumch@126.com

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- 文章访问数: 19
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出版历程
- 收稿日期: 2023-06-05
- 修回日期: 2023-07-17
- 网络出版日期: 2023-08-03

Research Progress on the Mechanism of Infection in Autoimmune Diseases

CHENG Linlin^1,2,
LI Zhan^1,2,
LI Yongzhe^{1,2
, ,}

1 Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China;
2 State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100730, China

Funds:

National Key Research and Development Program of China (2018YFE0207300)

摘要

摘要: 自身免疫性疾病（autoimmune disease, AID）发病机制复杂。近年来，越来越多的证据表明，感染在驱动具有潜在遗传背景的AID的发生和进展中起关键作用，这为临床重新审视AID的诱因及可能机制提供了更广泛和新颖的视角。本文通过总结病原微生物与自身免疫/AID相关性的最新研究进展，旨在从病原学角度探讨常见AID的病因和发病机制，希望通过整合现有证据，加深对AID发病机制的认识，为疾病预防和临床诊疗提供有价值的见解。
- 自身免疫 /
- 发病机制 /
- 病原微生物 /
- 分子模拟 /
- 新型冠状病毒
Abstract: The pathogenesis of autoimmune diseases (AID) is a complex process. Recent evidence has increasingly shown that infection plays a key role in driving the occurrence and progression of AID, particularly in individuals with underlying genetic predisposition. This provides a new and broader perspective for clinical examination of the causes and potential mechanisms of AID. In this review, we aim to summarize the latest research progress on the relationship between pathogenic microorganisms and autoimmunity/AID, with the goal of exploring the etiology and pathogenesis of common AID from an etiological perspective. By integrating existing evidence, we hope to deepen the understanding of AID pathogenesis and provide valuable insights for disease prevention, clinical diagnosis, and treatment.
- autoimmunity /
- pathogenesis /
- pathogenic microorganisms /
- molecular mimicry /
- SARS-CoV-2

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感染在自身免疫性疾病中的作用机制

doi: 10.12290/xhyxzz.2023-0268

通讯作者:
李永哲,E-mail:yongzhelipumch@126.com

计量

Research Progress on the Mechanism of Infection in Autoimmune Diseases

计量

目录

留言板

感染在自身免疫性疾病中的作用机制

doi: 10.12290/xhyxzz.2023-0268

通讯作者: 李永哲,E-mail:yongzhelipumch@126.com

计量

出版历程

Research Progress on the Mechanism of Infection in Autoimmune Diseases

计量

出版历程

目录

通讯作者:
李永哲,E-mail:yongzhelipumch@126.com