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肝细胞癌根治性切除术后肝功能衰竭及预后模型研究进展

张垚,  赵成俊,  任宾,  杜磊,  马倩源

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张垚, 赵成俊, 任宾, 杜磊, 马倩源. 肝细胞癌根治性切除术后肝功能衰竭及预后模型研究进展[J]. 协和医学杂志. doi: 10.12290/xhyxzz.2023-0235
引用本文: 张垚, 赵成俊, 任宾, 杜磊, 马倩源. 肝细胞癌根治性切除术后肝功能衰竭及预后模型研究进展[J]. 协和医学杂志. doi: 10.12290/xhyxzz.2023-0235
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ZHANG Yao, ZHAO Chengjun, REN Bin, DU Lei, MA Qianyuan. Research Progress on Liver Failure and Prognosis Models after Radical Resection of Hepatocellular Carcinoma[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2023-0235
Citation: ZHANG Yao, ZHAO Chengjun, REN Bin, DU Lei, MA Qianyuan. Research Progress on Liver Failure and Prognosis Models after Radical Resection of Hepatocellular Carcinoma[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2023-0235
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肝细胞癌根治性切除术后肝功能衰竭及预后模型研究进展

doi: 10.12290/xhyxzz.2023-0235

  • 1 青海大学附属医院 肝胆胰外科, 西宁 810001;

  • 2 青海省包虫病研究重点实验室, 西宁 810001;

  • 3 青海大学附属医院 病理科, 西宁 810001

基金项目: 

2021年度青海省“昆仑英才·高端创新创业人才”资助项目

详细信息
    通讯作者:

    任宾,E-mail:35619452@qq.com

  • 中图分类号: R735.7；G353.11

Research Progress on Liver Failure and Prognosis Models after Radical Resection of Hepatocellular Carcinoma

  • 1 Department of Hepatopancreatobiliary Surgery, Qinghai University Affiliated Hospital, Xining 810001, China;

  • 2 Qinghai Province Key Laboratory of Hydatid Disease Research, Xining 810001, China;

  • 3 Department of Pathology, Qinghai University Affiliated Hospital, Xining 810001, China

Funds: 

2021 Qinghai Province "Kunlun Talents · High-end innovative and entrepreneurial talents" funding

    摘要
  • 摘要: 目前经典 Child-Pugh 分级法和终末期肝病模型（model for end-stageliver disease， MELD）被临床广泛用于术前评估肝细胞癌（liver cell carcinoma，HCC） 患者行根治性肝切除手术治疗后肝功能衰竭及预后情况。但受到白蛋白、腹水、血肌酐等因素的影响，二者的使用条件存在一定的局限性。 文献报道 HCC患者行根治性肝切除术后白蛋白-胆红素评分（ALBI）、血小板-白蛋白-胆红素评分（PALBI）、格拉斯哥预后评分（GPS）以及新型预测模型在评估 HCC 患者行肝切除术后肝功能衰竭及预后中具有良好应用前景。结合文献资料对经典、新型肝功能评分以及新型预测模型在 HCC 患者行肝切除术后的研究认为 PALBI 评分目前具有良好的应用价值。
    Abstract: The classical Child-Pugh classification and the Model for End-Stage Liver Disease (MELD) are now widely used clinically for preoperative assessment of liver failure and prognosis in patients with hepatocellular carcinoma (HCC) treated with radical hepatectomy. However, there are limitations in the conditions of use of both due to factors such as albumin, ascites, and blood creatinine. Review the relevant literature at home and abroad about liver failure and prognosis of HCC patients after radical Hepatectomy: albumin bilirubin score (ALBI), platelet albumin bilirubin score (PALBI), Glasgow Prognostic Score (GPS) and new predictive models have good application prospects in evaluating liver failure and prognosis of HCC patients after Hepatectomy. Combined with the literature, the study of the classic, new liver function scores and new predictive models after Hepatectomy in HCC patients shows that the PALBI score has good application value at present.
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