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小胶质细胞与NLRP3炎症小体在认知功能障碍中作用的研究进展

王彩红,  刘荣鑫,  汤峰,  魏晓涛,  徐紫清,  侯怀晶,  张杰,  赵永强,  薛建军

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文章导航 > 协和医学杂志  > 2023 > 优先出版
王彩红, 刘荣鑫, 汤峰, 魏晓涛, 徐紫清, 侯怀晶, 张杰, 赵永强, 薛建军. 小胶质细胞与NLRP3炎症小体在认知功能障碍中作用的研究进展[J]. 协和医学杂志. doi: 10.12290/xhyxzz.2023-0217
引用本文: 王彩红, 刘荣鑫, 汤峰, 魏晓涛, 徐紫清, 侯怀晶, 张杰, 赵永强, 薛建军. 小胶质细胞与NLRP3炎症小体在认知功能障碍中作用的研究进展[J]. 协和医学杂志. doi: 10.12290/xhyxzz.2023-0217
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WANG Caihong, LIU Rongxin, TANG Feng, WEI Xiaotao, XU Ziqing, HOU Huaijing, ZHANG Jie, ZHAO Yongqiang, XUE Jianjun. Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2023-0217
Citation: WANG Caihong, LIU Rongxin, TANG Feng, WEI Xiaotao, XU Ziqing, HOU Huaijing, ZHANG Jie, ZHAO Yongqiang, XUE Jianjun. Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2023-0217
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小胶质细胞与NLRP3炎症小体在认知功能障碍中作用的研究进展

doi: 10.12290/xhyxzz.2023-0217

  • 1 甘肃中医药大学第一临床医学院, 兰州 730000;

  • 2 甘肃省中医院 麻醉科, 兰州 730000;

  • 3 甘肃省中医院 甘肃省中西医结合麻醉临床研究中心, 兰州 730000;

  • 4 甘肃省中医院 甘肃省中医药研究 院中西医结合麻醉与循证医学研究所, 兰州 730000;

  • 5 甘肃省中医院 泌尿外科, 兰州 730000

基金项目: 

甘肃省科技计划项目-临床医学研究中心建设（20JR10RA435）；甘肃省科技计划项目-重点研发计划（22YF7FA101）

详细信息
    通讯作者:

    赵永强,E-mail:1114221808@qq.com

    薛建军,E-mail:xjjfei419@162.com

  • 中图分类号: R614.4; R741; R364.5

Research Progress on the Role of NLRP3 Inflammasome and Microglia in Cognitive Impairment

  • 1 First Clinical Medical School, Gansu University of Chinese Medicine, Lanzhou 730000, China;

  • 2 Department of Anesthesiology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000;

  • 3 Gansu Province Integrative Medicine Anesthesia Clinical Research Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000;

  • 4 Gansu Provincial Institute of Traditional Chinese and Western Medicine Anesthesia and Evidence-based Medicine Institute, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000;

  • 5 Department of Urology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000

Funds: 

Gansu Provincial Science and Technology Plan Project-Construction of Clinical Medical Research Center(20JR10RA435)

    摘要
  • 摘要: 认知功能障碍作为一种常见的神经系统疾病，以认知减退、记忆力和注意力障碍为其主要临床表现，严重影响患者的生活质量，是当前医学研究的热点和难点。认知功能障碍病因病机复杂多样，研究表明慢性持续性神经炎症在其发生发展中发挥关键作用。小胶质细胞、核苷酸结合寡聚化结构域样受体蛋白3（ nucleotide-binding oligomerization domainlike receptor protein 3，NLRP3）炎症小体与神经炎症、认知功能障碍密切相关，调控小胶质细胞、NLRP3炎症小体可减少炎症因子、减少β淀粉样蛋白沉积、调控自噬、维持突触稳态，达到减轻神经炎症，进而防治认知功能障碍的作用。因此，探讨小胶质细胞、NLRP3炎症小体及其二者共同在认知功能障碍中的作用机制，为认知功能障碍相关作用机制的深入研究及临床防治、药物研发提供一定的参考和依据。
    Abstract: As a common neurological disease, cognitive impairment is characterized by cognitive decline, memory and attention impairment, which seriously affects the quality of life of patients. It is a hot and difficult point in the field of medical research. The etiology and pathogenesis of cognitive impairment are complex and diverse. Studies have shown that chronic persistent neuroinflammation plays a key role in its development. Microglia and Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome are closely related to neuroinflammation and cognitive impairment. Regulation of microglia and NLRP3 inflammasome can reduce inflammatory factors, reduce amyloid β-protein (Aβ) deposition, regulate autophagy, maintain synaptic homeostasis, and reduce neuroinflammation. In turn, the role of prevention and treatment of cognitive impairment. Therefore, summarizing and discussing the mechanism of microglia, NLRP3 inflammasome and their interaction in cognitive impairment can provide some reference and basis for the in-depth study of the mechanism of cognitive impairment, clinical prevention and treatment of cognitive impairment, and the subsequent development of more efficient drugs.
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  • 收稿日期:  2023-04-27
  • 网络出版日期:  2023-09-05

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