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The Impact of Gut Microbiota on Vaccine Immune Efficacy and Potential Mechanisms
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摘要:
疫苗是防止传染病传播最有效的方法，但其诱导的免疫反应在不同地区个体和人群之间存在显著差异。 最新研究表明， 肠道微生物群的组成和功能对疫苗接种后的免疫反应发挥关键作用。本文旨在阐述肠道微生物群在接种疫苗的不同人群、动物间的差异，探讨肠道微生物群对疫苗免疫效力的影响及可能机制，并阐述靶向肠道微生物群改善疫苗有效性的策略。
Abstract:Vaccine is the most effective method to prevent the spread of communicable diseases， but the immune response it induces varies significantly among individuals and populations in different regions. Recent studies have shown that the composition and function of the gut microbiota play a key role in the immune response following vaccination. This article aims to explain the differences in gut microbiota among different populations and animals when vaccinated， discuss how the gut microbiota affects the immune efficacy of the vaccine， and summarize strategies for targeting the gut microbiota to improve vaccine efficacy.
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Key words:
- gut microbiota /
- vaccine /
- immune efficacy
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