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Omicron变异株病毒学特征: 关键突变、致病性、免疫逃逸

陈玉清 李金明

陈玉清, 李金明. Omicron变异株病毒学特征: 关键突变、致病性、免疫逃逸[J]. 协和医学杂志, 2023, 14(5): 945-952. doi: 10.12290/xhyxzz.2023-0139
引用本文: 陈玉清, 李金明. Omicron变异株病毒学特征: 关键突变、致病性、免疫逃逸[J]. 协和医学杂志, 2023, 14(5): 945-952. doi: 10.12290/xhyxzz.2023-0139
CHEN Yuqing, LI Jinming. Virological Characteristics of the Omicron Variant: Key Mutations, Pathogenicity, and Immune Escape[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 945-952. doi: 10.12290/xhyxzz.2023-0139
Citation: CHEN Yuqing, LI Jinming. Virological Characteristics of the Omicron Variant: Key Mutations, Pathogenicity, and Immune Escape[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 945-952. doi: 10.12290/xhyxzz.2023-0139

Omicron变异株病毒学特征: 关键突变、致病性、免疫逃逸

doi: 10.12290/xhyxzz.2023-0139
详细信息
    通讯作者:

    李金明,E-mail:jmli@nccl.org.cn

  • 中图分类号: R446.5;R51

Virological Characteristics of the Omicron Variant: Key Mutations, Pathogenicity, and Immune Escape

More Information
  • 摘要: 新型冠状病毒(severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) Omicron变异株首次在博茨瓦纳被检出, 随后造成了全世界范围内的感染人数激增。截至目前, Omicron是需要关注的SARS-CoV-2变异株中突变数量最多的毒株, 已在整个基因组中发生至少50次突变。Omicron基因组发生的突变赋予病毒一定的适应性优势, 如受体结合域与人类血管紧张素转换酶2受体亲和力增强导致病毒传播能力增强; 与先前变异株相比, 病毒复制能力减弱导致在COVID-19患者中引起的症状相对较轻。此外, 该变异株具有较高的环境稳定性, 部分逃脱了来自疫苗接种或先前感染诱导的宿主免疫反应, 且对大多数治疗性抗体具有较高的耐药性。本文对Omicron变异株的关键突变、病毒学特征、致病性和免疫逃逸能力进行总结, 以期为完善疫情防控策略和公共卫生举措提供科学参考。
    作者贡献:陈玉清负责资料收集和论文撰写;李金明负责选题设计并审阅定稿。
    利益冲突:所有作者均声明不存在利益冲突
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出版历程
  • 收稿日期:  2023-03-21
  • 录用日期:  2023-05-05
  • 网络出版日期:  2023-05-08
  • 刊出日期:  2023-09-30

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