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硼中子俘获疗法的原理及临床应用

刘志凯,  程炜诗,  吴王锁,  梁天骄,  邢庆子,  张紫竹,  刘志博,  刘渊豪,  潘建基,  朱晒红,  李晴暖,  张福泉,  邱杰,  霍力

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文章导航 > 协和医学杂志  > 2023 >  14(4): 698-705
刘志凯, 程炜诗, 吴王锁, 梁天骄, 邢庆子, 张紫竹, 刘志博, 刘渊豪, 潘建基, 朱晒红, 李晴暖, 张福泉, 邱杰, 霍力. 硼中子俘获疗法的原理及临床应用[J]. 协和医学杂志, 2023, 14(4): 698-705. doi: 10.12290/xhyxzz.2023-0120
引用本文: 刘志凯, 程炜诗, 吴王锁, 梁天骄, 邢庆子, 张紫竹, 刘志博, 刘渊豪, 潘建基, 朱晒红, 李晴暖, 张福泉, 邱杰, 霍力. 硼中子俘获疗法的原理及临床应用[J]. 协和医学杂志, 2023, 14(4): 698-705. doi: 10.12290/xhyxzz.2023-0120
shu
LIU Zhikai, CHENG Weishi, WU Wangsuo, LIANG Tianjiao, XING Qingzi, ZHANG Zizhu, LIU Zhibo, LIU Yuanhao, PAN Jianji, ZHU Shaihong, LI Qingnuan, ZHANG Fuquan, QIU Jie, HUO Li. Principles and Clinical Applications of Boron Neutron Capture Therapy[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(4): 698-705. doi: 10.12290/xhyxzz.2023-0120
Citation: LIU Zhikai, CHENG Weishi, WU Wangsuo, LIANG Tianjiao, XING Qingzi, ZHANG Zizhu, LIU Zhibo, LIU Yuanhao, PAN Jianji, ZHU Shaihong, LI Qingnuan, ZHANG Fuquan, QIU Jie, HUO Li. Principles and Clinical Applications of Boron Neutron Capture Therapy[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(4): 698-705. doi: 10.12290/xhyxzz.2023-0120
shu

硼中子俘获疗法的原理及临床应用

doi: 10.12290/xhyxzz.2023-0120
  • 1.

    中国医学科学院北京协和医院放射治疗科，北京 100730

  • 2.

    兰州大学核科学与技术学院, 兰州 730000

  • 3.

    中国科学院高能物理研究所，广东东莞 100049

  • 4.

    清华大学工程物理系，北京 100084

  • 5.

    北京核工业医院，北京 100045

  • 6.

    北京大学化学与分子工程学院，北京 100871

  • 7.

    中硼(厦门)医疗器械有限公司，福建厦门 361028

  • 8.

    福建医科大学，福州 350122

  • 9.

    中南大学湘雅三医院，长沙 410013

  • 10.

    中国科学院上海应用物理研究所，上海 201800

  • 11.

    中国医学科学院北京协和医院核医学科，北京 100730

详细信息
    通讯作者:

    霍力, E-mail: huoli@pumch.cn

  • 中图分类号: R45;R73

Principles and Clinical Applications of Boron Neutron Capture Therapy

  • 1.

    Department of Radiotherapy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000, China

  • 3.

    Institute of High Energy Physics, Chinese Academy of Sciences, Dongguan, Guangdong 100049, China

  • 4.

    Department of Engineering Physics, Tsinghua University, Beijing 100084, China

  • 5.

    Beijing Nuclear Industry Hospital, Beijing 100045, China

  • 6.

    School of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

  • 7.

    China Boron (Xiamen) Medical Devices Co., Ltd., Xiamen, Fujian 361028, China

  • 8.

    Fujian Medical University, Fuzhou 350122, China

  • 9.

    The Third Xiangya Hospital of Central South University, Changsha 410013, China

  • 10.

    Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China

  • 11.

    Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

More Information

    摘要
  • 摘要: 硼中子俘获疗法(Boron neutron capture therapy, BNCT)是一项处于快速发展中的先进放疗技术。该技术通过在癌细胞内发生的10B(n, α)7Li原子核反应杀死癌细胞，是一种原子级别的二元靶向治疗，其临床实施需要专业技术与装置支持。BNCT的核心要素包括适宜的中子源及中子俘获药物。相较于传统放疗技术，BNCT在治疗局部复发肿瘤(如中枢神经系统肿瘤和头颈部肿瘤)中优势突出，能够更好地保护正常器官，特别是对于已经对周围器官产生明显侵犯的肿瘤具有良好的应用前景。本文主要阐述BNCT的技术原理、核心要素及其临床应用，以期为临床诊疗提供参考。
    Abstract: Boron neutron capture therapy (BNCT) is an advanced radiation therapy technique that is rapidly developing in the field of cancer treatment. This technique, an atomic-level binary targeted therapy, kills cancer cells by causing a 10B(n, α)7Li nuclear reaction within the cancer cells, and its clinical implementation requires professional technology and device support. The core elements of BNCT include appropriate neutron sources and neutron capture drugs. Compared with traditional radiotherapy techniques, BNCT shows outstanding advantages in treating locally recurrent tumors, such as central nervous system tumors and head and neck tumors. Furthermore, it can better protect normal organs, especially for tumors that have already significantly invaded surrounding organs, demonstrating its promising future prospects. This article mainly elaborates on the technical principles, core elements, and clinical applications of BNCT, in hope of providing reference for clinical diagnosis and treatment.
    作者贡献：刘志凯负责设计论文框架，调研整理文献，撰写论文初稿及修订论文；程炜诗负责调研整理文献，参与撰写论文初稿及论文修订；吴王锁、梁天骄、邢庆子、张紫竹、刘志博、刘渊豪、潘建基、朱晒红、李晴暖、张福泉、邱杰负责调研整理文献；霍力负责指导修订、审核论文。
    利益冲突：所有作者均声明不存在利益冲突
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  • 图  1  硼中子俘获疗法基本原理示意图

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