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中华医学会儿科学分会免疫学组, 中国儿童风湿免疫病联盟, 国家儿童健康与疾病临床研究中心风湿免疫联盟. 幼年特发性关节炎相关葡萄膜炎诊疗中国专家共识(2023)[J]. 协和医学杂志, 2023, 14(2): 247-256. doi: 10.12290/xhyxzz.2023-0090
引用本文: 中华医学会儿科学分会免疫学组, 中国儿童风湿免疫病联盟, 国家儿童健康与疾病临床研究中心风湿免疫联盟. 幼年特发性关节炎相关葡萄膜炎诊疗中国专家共识(2023)[J]. 协和医学杂志, 2023, 14(2): 247-256. doi: 10.12290/xhyxzz.2023-0090
The Subspecialty Group of Immunology, the Society of Pediatrics, Chinese Medical Association, Chinese Alliance of Pediatric Rheumatic and Immunologic Diseases, Alliance of Rheumatic and Immunologic Diseases, National Clinical Research Center for Child Health and Disorders. Chinese Expert Consensus on Juvenile Idiopathic Arthritis-associated Uveitis (2023)[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 247-256. doi: 10.12290/xhyxzz.2023-0090
Citation: The Subspecialty Group of Immunology, the Society of Pediatrics, Chinese Medical Association, Chinese Alliance of Pediatric Rheumatic and Immunologic Diseases, Alliance of Rheumatic and Immunologic Diseases, National Clinical Research Center for Child Health and Disorders. Chinese Expert Consensus on Juvenile Idiopathic Arthritis-associated Uveitis (2023)[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 247-256. doi: 10.12290/xhyxzz.2023-0090

幼年特发性关节炎相关葡萄膜炎诊疗中国专家共识(2023)

doi: 10.12290/xhyxzz.2023-0090
基金项目: 

国家重点研发计划 2021YFC2702003

详细信息

    通信作者:唐雪梅1,E-mail:tangxuemei2008@163.com
    宋红梅2,E-mail:vsonghm1021@126.com
    1. 重庆医科大学附属儿童医院风湿免疫科,重庆 400014
    2. 中国医学科学院北京协和医院儿科,北京 100730

  • 中图分类号: R593.22; R725.9

Chinese Expert Consensus on Juvenile Idiopathic Arthritis-associated Uveitis (2023)

Funds: 

National Key Research and Development Program of China 2021YFC2702003

More Information

    Corresponding authors: TANG Xuemei1, E-mail: tangxuemei2008@163.com
    SONG Hongmei2, E-mail: songhm1021@126.com
    1. Department of Immunology and Rheumatology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China
    2. Department of Pediatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 摘要: 幼年特发性关节炎(juvenile idiopathic arthritis,JIA)是儿童时期常见的风湿免疫性疾病。幼年特发性关节炎相关葡萄膜炎(juvenile idiopathic arthritis-associated uveitis,JIA-U)是JIA重要的关节外并发症,主要表现为隐匿起病的虹膜和睫状体前部非肉芽肿性炎症(虹膜睫状体炎),是造成儿童时期残疾和失明的重要原因之一。近年来,美国风湿病学会(American College of Rheumatology,ACR)及欧洲儿科风湿病学的单一枢纽和接入点(Single Hub and Access Point for Pediatric Rheumatology in Europe,SHARE)先后均发表了JIA-U的临床指南,但我国尚缺乏诊疗相关指导性文件。为进一步加强该病的临床认知和诊疗规范,中华医学会儿科学分会免疫学组、中国儿童风湿免疫病联盟、国家儿童健康与疾病临床研究中心风湿免疫联盟联合眼科专家共同制定了《幼年特发性关节炎相关葡萄膜炎诊疗中国专家共识(2023)》,在疾病筛查、诊断、治疗等方面达成初步共识,以供临床参考。
    作者贡献:本专家共识由中华医学会儿科学分会免疫学组、中国儿童风湿免疫病联盟、国家儿童健康与疾病临床研究中心风湿免疫联盟发起,宋红梅、唐雪梅牵头成立指南制订工作组,杨曦起草本共识初稿并负责主要撰写工作,专家组成员共同进行讨论和投票, 杨培增、张美芬参与凝练本指南推荐意见。
    利益冲突:所有参与本共识制订的人员均声明不存在利益冲突
    核心专家组 (按姓氏首字母排序):宋红梅(中国医学科学院北京协和医院儿科),孙利(复旦大学附属儿科医院风湿科),唐雪梅(重庆医科大学附属儿童医院风湿免疫科),杨军(深圳市儿童医院风湿免疫科),杨培增(重庆医科大学附属第一医院眼科),张美芬(中国医学科学院北京协和医院眼科)
    工作组 (按姓氏首字母排序):安云飞(重庆医科大学附属儿童医院风湿免疫科),郝胜(上海市儿童医院肾脏风湿免疫科),蒋新辉(贵阳市妇幼保健院儿童风湿免疫科),李建国(首都儿科研究所附属儿童医院风湿免疫科),李小青(西安市儿童医院风湿免疫科),李晓忠(苏州大学附属儿童医院肾脏免疫科),刘勍(重庆医科大学附属儿童医院眼科),刘小惠(江西省儿童医院风湿免疫科),卢美萍(浙江大学附属儿童医院风湿免疫科),毛华伟(首都医科大学附属儿童医院免疫科),唐琳(重庆医科大学附属第二医院风湿免疫科),王亚军(云南省第一人民医院儿科),吴小川(中南大学湘雅二医院儿科),杨思睿(吉林大学第一医院儿童风湿免疫过敏科),俞海国(南京医科大学附属儿童医院风湿免疫科),张秋业(青岛大学附属儿童医院儿科),张伟(成都市妇女儿童中心医院儿童风湿免疫科),赵冬梅[乌鲁木齐市第一人民医院(儿童医院)风湿免疫科],曾萍(广州市妇女儿童医疗中心风湿免疫科),郑雯洁(温州医科大学附属第二医院儿童风湿科),周纬(上海儿童医学中心肾脏风湿科)
    秘书组:杨曦(重庆医科大学附属儿童医院风湿免疫科),马明圣(中国医学科学院北京协和医院儿科),刘大玮(重庆医科大学附属儿童医院风湿免疫科),王玉莲(重庆医科大学附属儿童医院风湿免疫科)
    执笔人:杨曦,唐雪梅,马明圣,宋红梅
  • 图  1  JIA-U眼科筛查建议[6]

    JIA-U:幼年特发性关节炎相关葡萄膜炎;ANA、RF:同表 1

    表  1  国际两种JIA分型方法[1-2]

    2001年国际风湿病协会联盟
    JIA分型
    2018年国际儿童风湿病试验组织
    JIA分型
    全身型JIA 全身型JIA
    少关节炎型JIA RF阳性JIA
    RF阳性多关节炎型JIA 附着点炎/脊柱关节炎相关性JIA
    RF阴性多关节炎型JIA 早发性ANA阳性JIA
    银屑病性关节炎 其他类型JIA
    附着点炎相关性关节炎 未分类JIA
    未分化关节炎
    JIA:幼年特发性关节炎;RF:类风湿因子; ANA: 抗核抗体
    下载: 导出CSV

    表  2  2001年牛津循证医学中心推荐强度和证据等级分类

    推荐强度 证据等级 描述
    A 1a 同质随机对照试验的系统评价
    1b 单项随机对照试验
    1c “全或无”证据(有治疗之前所有患者死亡,有治疗之后,有患者能存活;或者有治疗之前部分患者死亡,有治疗之后无患者死亡)
    B 2a 同质队列研究的系统评价
    2b 单项队列研究(包括低质量的随机对照试验,如<80%随访)
    2c 结果研究,生态学研究
    3a 同质病例对照研究的系统评价
    3b 单项病例对照研究
    C 4 病例报道(低质量队列研究)
    D 5 基于未经验证的专家意见或评论
    下载: 导出CSV

    表  3  葡萄膜炎活动期标准化命名[23]

    病情等级 定义
    不活跃 0级细胞(前房或玻璃体)
    活动恶化 炎症水平增加2级(如前房细胞、玻璃体混浊)或从3+级增至4+级
    活动改善 炎症水平降低2级(如前房细胞、玻璃体混浊)或减至0级
    缓解 停用所有药物后非活动性炎症时间>3个月
    下载: 导出CSV
  • [1] Petty RE, Southwood TR, Manners P, et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001[J]. J Rheumatol, 2001, 31: 390-392.
    [2] Martini A, Ravelli A, Avcin T, et al. Toward New Classification Criteria for Juvenile Idiopathic Arthritis: First Steps, Pediatric Rheumatology International Trials Organization International Consensus[J]. J Rheumatol, 2019, 46: 190-197. doi:  10.3899/jrheum.180168
    [3] Bou R, Adán A, Borrás F, et al. Clinical management algorithm of uveitis associated with juvenile idiopathic arthritis: interdisciplinary panel consensus[J]. Rheumatol Int, 2015, 35: 777-785. doi:  10.1007/s00296-015-3231-3
    [4] Heiligenhaus A, Niewerth M, Ganser G, et al. Prevalence and complications of uveitis in juvenile idiopathic arthritis in a population-based nation-wide study in Germany: suggested modification of the current screening guidelines[J]. Rheumatology (Oxford), 2007, 46: 1015-1019. doi:  10.1093/rheumatology/kem053
    [5] Constantin T, Foeldvari I, Anton J, et al. Consensus-based recommendations for the management of uveitis associated with juvenile idiopathic arthritis: the SHARE initiative[J]. Ann Rheum Dis, 2018, 77: 1107-1117.
    [6] Angeles-Han ST, Ringold S, Beukelman T, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis[J]. Arthritis Care Res (Hoboken), 2019, 71: 703-716. doi:  10.1002/acr.23871
    [7] Sim KT, Venning HE, Barrett S, Gregson RM, et al. Extended oligoarthritis and other risk factors for developing JIA-associated uveitis under ILAR classification and its implication for current screening guideline[J]. Ocul Immunol Inflamm, 2006, 14: 353-357. doi:  10.1080/09273940600977233
    [8] Saurenmann RK, Levin AV, Feldman BM, et al. Prevalence, risk factors, and outcome of uveitis in juvenile idiopathic arthritis: A long-term followup study[J]. Arthritis Rheum, 2007, 56: 647-657. doi:  10.1002/art.22381
    [9] Nordal E, Rypdal V, Christoffersen T, et al. Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study[J]. Pediatr Rheumatol, 2017, 15: 1-8. doi:  10.1186/s12969-016-0134-0
    [10] Ringold S, Angeles-Han ST, Beukelman T, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis[J]. Arthritis Care Res, 2019, 71: 717-734. doi:  10.1002/acr.23870
    [11] Curtis JR, Johnson SR, Anthony DD, et al. American College of Rheumatology Guidance for COVID‐19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 2[J]. Arthritis Rheumatol, 2021, 73: 1-16.
    [12] Lee JJY, Duffy CM, Guzman J, et al. Prospective Determination of the Incidence and Risk Factors of New-Onset Uveitis in Juvenile Idiopathic Arthritis: The Research in Arthritis in Canadian Children Emphasizing Outcomes Cohort[J]. Arthritis Care Res, 2019, 71: 1436-1443. doi:  10.1002/acr.23783
    [13] Guillaume S, Prieur AM, Coste J, Job-Deslandre C. Long-term outcome and prognosis in oligoarticular-onset juvenile idiopathic arthritis[J]. Arthritis Rheum, 2000, 43: 1858-1865. doi:  10.1002/1529-0131(200008)43:8<1858::AID-ANR23>3.0.CO;2-A
    [14] Sabri K, Saurenmann RK, Silverman ED, et al. Course, complications, and outcome of juvenile arthritis-related uveitis[J]. J AAPOS, 2008, 12: 539-545. doi:  10.1016/j.jaapos.2008.03.007
    [15] Cassidy J, Kivlin J, Lindsley C, et al. Ophthalmologic examinations in children with juvenile rheumatoid arthritis[J]. Pediatrics, 2006, 117: 1843-1845. doi:  10.1542/peds.2006-0421
    [16] Hoeve M, Ayuso VK, Schalij-Delfos NE, et al. The clinical course of juvenile idiopathic arthritis-associated uveitis in childhood and puberty[J]. Br J Ophthalmol, 2012, 96: 852-856. doi:  10.1136/bjophthalmol-2011-301023
    [17] Angeles-Han ST, McCracken C, Yeh S, et al. Characteris-tics of a cohort of children with Juvenile Idiopathic Arthritis and JIA-associated Uveitis[J]. Pediatr Rheumatol, 2015, 13: 15-17. doi:  10.1186/s12969-015-0011-2
    [18] Vastert SJ, Bhat P, Goldstein DA. Pathophysiology of JIA-associated Uveitis[J]. Ocul Immunol Inflamm, 2014, 22: 414-423. doi:  10.3109/09273948.2014.926937
    [19] Du L, Kijlstra A, Yang P. Immune response genes in uveitis[J]. Ocul Immunol Inflamm, 2009, 17: 249-256. doi:  10.1080/09273940902999356
    [20] Tappeiner C, Klotsche J, Sengler C, et al. Risk Factors and Biomarkers for the Occurrence of Uveitis in Juvenile Idiopathic Arthritis: Data From the Inception Cohort of Newly Diagnosed Patients With Juvenile Idiopathic Arthritis Study[J]. Arthritis Rheumatol, 2018, 70: 1685-1694. doi:  10.1002/art.40544
    [21] Vitale AT, Graham E, De Boer JH. Juvenile idiopathic arthritis-associated uveitis: Clinical features and complica-tions, risk factors for severe course, and visual outcome[J]. Ocul Immunol Inflamm, 2013, 21: 478-485. doi:  10.3109/09273948.2013.815785
    [22] Heiligenhaus A, Foeldvari I, Edelsten C, et al. Proposed outcome measures for prospective clinical trials in juvenile idiopathic arthritis-associated uveitis: A consensus effort from the multinational interdisciplinary working group for uveitis in childhood[J]. Arthritis Care Res, 2012, 64: 1365-1372. doi:  10.1002/acr.21674
    [23] Jabs DA, Nussenblatt RB, Rosenbaum JT, et al. Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop[J]. Am J Ophthalmol, 2005, 140: 509-516. doi:  10.1016/j.ajo.2005.03.057
    [24] Clarke SLN, Sen ES, Ramanan AV. Juvenile idiopathic arthritis-associated uveitis[J]. Pediatr Rheumatol, 2016, 14: 1-11. doi:  10.1186/s12969-015-0062-4
    [25] Thorne JE, Woreta F, Kedhar SR, et al. Juvenile Idiopathic Arthritis-Associated Uveitis: Incidence of Ocular Complications and Visual Acuity Loss[J]. Am J Ophthalmol, 2007, 143: 840-846. doi:  10.1016/j.ajo.2007.01.033
    [26] Zannin ME, Martini G, Buscain I, et al. Sudden visual loss in a child with juvenile idiopathic arthritis-related uveitis[J]. Br J Ophthalmol, 2009, 93: 282-283. doi:  10.1136/bjo.2008.137794
    [27] Heinz C, Schumacher C, Roesel M, et al. Elevated intraocular pressure in uveitis associated with juvenile idiopathic arthritis-associated uveitis, often detected after achieving inactivity[J]. Br J Ophthalmol, 2012, 96: 140-141. doi:  10.1136/bjophthalmol-2011-300731
    [28] Grassi A, Corona F, Casellato A, et al. Prevalence and outcome of juvenile idiopathic arthritis- associated uveitis and relation to articular disease[J]. J Rheumatol, 2007, 34: 1139-1145.
    [29] Lerman MA, Lewen MD, Kempen JH, et al. Uveitis reactivation in children treated with tumor necrosis factor α inhibitors[J]. Am J Oph-thalmol, 2015, 160: 193-200. doi:  10.1016/j.ajo.2015.04.016
    [30] Kotaniemi K, Sihto-Kauppi K, Salomaa P, et al. The frequency and outcome of uveitis in patients with newly diagnosed juvenile idiopathic arthritis in two 4-year cohorts from 1990-1993 and 2000—2003[J]. Clin Exp Rheumatol, 2014, 32: 143-147.
    [31] Heiligenhaus A, Michels H, Schumacher C, et al. Evidence-based, interdisciplinary guidelines for anti-inflammatory treatment of uveitis associated with juvenile idiopathic arthritis[J]. Rheumatol Int, 2012, 32: 1121-1133. doi:  10.1007/s00296-011-2126-1
    [32] Foster CS, Alter G, DeBarge LR, et al. Efficacy and safety of rimexolone 1% ophthalmic suspension vs 1% prednisolone acetate in the treatment of uveitis[J]. Am J Ophthalmol, 1996, 122: 171-182. doi:  10.1016/S0002-9394(14)72008-2
    [33] Heiligenhaus A, Minden K, Tappeiner C, et al. Update of the evidence based, interdisciplinary guideline for anti-inflammatory treatment of uveitis associated with juvenile idiopathic arthritis[J]. Semin Arthritis Rheum, 2019, 49: 43-55. doi:  10.1016/j.semarthrit.2018.11.004
    [34] Simonini G, Cantarini L, Bresci C, et al. Current thera-peutic approaches to autoimmune chronic uveitis in children[J]. Autoimmun Rev, 2010, 9: 674-683. doi:  10.1016/j.autrev.2010.05.017
    [35] Edelsten C, Reddy MA, Stanford MR, et al. Visual loss associated with pediatric uveitis in English primary and referral centers[J]. Am J Ophthalmol, 2003, 135: 676-680. doi:  10.1016/S0002-9394(02)02148-7
    [36] Olson NY, Lindsley CB, Godfrey WA. Nonsteroidal Anti-inflammatory Drug Therapy in Chronic Childhood Iridocyclitis[J]. Am J Dis Child, 1988, 142: 1289-1292.
    [37] Sijssens KM, rothova A, Van de Vijver dA, et al. risk factors for the development of cataract requiring surgery in uveitis associated with juvenile idiopathic arthritis[J]. Am J Ophthalmol, 2007, 144: 574-579. doi:  10.1016/j.ajo.2007.06.030
    [38] Thorne JE, Woreta FA, dunn JP, et al. risk of cataract development among children with juvenile idiopathic arthritis-related uveitis treated with topical corticosteroids[J]. Ophthalmology, 2010, 117: 1436-1441. doi:  10.1016/j.ophtha.2009.12.003
    [39] Kalinina Ayuso V, Van De Winkel EL, Rothova A, et al. Relapse rate of uveitis post-methotrexate treatment in juvenile idiopathic arthritis[J]. Am J Ophthalmol, 2011, 151: 217-222. doi:  10.1016/j.ajo.2010.08.021
    [40] Simonini G, Paudyal P, Jones GT, et al. Current evidence of methotrexate efficacy in childhood chronic uveitis: A systematic review and meta-analysis approach[J]. Rheumatol (United Kingdom), 2013, 52: 825-831.
    [41] Tappeiner C, Roesel M, Heinz C, et al. Limited value of cyclosporine A for the treatment of patients with uveitis associated with juvenile idiopathic arthritis[J]. Eye, 2009, 23: 1192-1198. doi:  10.1038/eye.2008.174
    [42] Angeles-Han ST, Lo MS, Henderson LA, et al. Childhood arthritis and rheumatology research alliance consensus treatment plans for juvenile idiopathic arthritis-Associated and idiopathic chronic anterior uveitis[J]. Arthritis Care Res, 2019, 71: 482-491. doi:  10.1002/acr.23610
    [43] Little JA, Sen ES, Strike H, et al. The safety and efficacy of noncorticosteroid triple immunosuppressive therapy in the treatment of refractory chronic noninfectious uveitis in childhood[J]. J Rheumatol, 2014, 41: 136-139. doi:  10.3899/jrheum.130594
    [44] Rosenbaum JT, George RK, Gordon C. The treatment of refractory uveitis with intravenous immunoglobulin[J]. Am J Ophthalmol, 1999, 127: 545-549. doi:  10.1016/S0002-9394(99)00029-X
    [45] Ayuso VK, ten Cate HAT, van der Does P, et al. Male Gender and Poor Visual Outcome in Uveitis Associated With Juvenile Idiopathic Arthritis[J]. Am J Ophthalmol, 2010, 149: 987-993. doi:  10.1016/j.ajo.2010.01.014
    [46] Zannin ME, Buscain I, Vittadello F, et al. Timing of uveitis onset in oligoarticular juvenile idiopathic arthritis (JIA) is the main predictor of severe course uveitis[J]. Acta Ophthalmol, 2012, 90: 91-95. doi:  10.1111/j.1755-3768.2009.01815.x
    [47] Sen ES, Morgan MJ, MacLeod R, et al. Cross sectional, qualitative thematic analysis of patient perspectives of disease impact in juvenile idiopathic arthritis-associated uveitis[J]. Pediatr Rheumatol, 2017, 15: 1-8. doi:  10.1186/s12969-016-0134-0
    [48] Heiligenhaus A, Klotsche J, Tappeiner C, et al. Predictive factors and biomarkers for the 2-year outcome of uveitis in juvenile idiopathic arthritis: Data from the Inception Cohort of Newly diagnosed patients with Juvenile Idiopathic Arthritis (ICON-JIA) study[J]. Rheumatol (United Kingdom), 2019, 58: 975-986.
    [49] Simonini G, Druce K, Cimaz R, et al. Current evidence of anti-tumor necrosis factor α treatment efficacy in childhood chronic uveitis: A systematic review and meta-analysis approach of individual drugs[J]. Arthritis Care Res, 2014, 66: 1073-1084. doi:  10.1002/acr.22214
    [50] Ramanan AV, Dick AD, Jones AP, et al. Adalimumab plus Methotrexate for Uveitis in Juvenile Idiopathic Arthritis[J]. N Engl J Med, 2017, 376: 1637-1646. doi:  10.1056/NEJMoa1614160
    [51] Quartier P, Baptiste A, Despert V, et al. ADJUVITE: A double-blind, randomised, placebo-controlled trial of adalimumab in early onset, chronic, juvenile idiopathic arthritis-associated anterior uveitis[J]. Ann Rheum Dis, 2018, 77: 1003-1011. doi:  10.1136/annrheumdis-2017-212089
    [52] Palmou-Fontana N, Calvo-Río V, Martín-Varillas JL, et al. Golimumab in refractory uveitis associated to juvenile idiopathic arthritis: multicentre study of 7 cases and literature review[J]. Clin Exp Rheumatol, 2018, 36: 652-657.
    [53] Lanz S, Seidel G, Skrabl-Baumgartner A. Golimumab in juvenile idiopathic arthritis-associated uveitis unresponsive to Adalimumab[J]. Pediatr Rheumatol, 2021, 19: 1-6. doi:  10.1186/s12969-020-00490-1
    [54] Smith JA, Thompson DJS, Whitcup SM, et al. A randomized, placebo-controlled, double-masked clinical trial of etanercept for the treatment of uveitis associated with juvenile idiopathic arthritis[J]. Arthritis Care Res, 2005, 53: 18-23. doi:  10.1002/art.20904
    [55] Tynjälä P, Lindahl P, Honkanen V, et al. Infliximab and etanercept in the treatment of chronic uveitis associated with refractory juvenile idiopathic arthritis[J]. Ann Rheum Dis, 2007, 66: 548-550.
    [56] Schmeling H, Horneff G. Etanercept and uveitis in patients with juvenile idiopathic arthritis[J]. Rheumatology, 2005, 44: 1008-1011. doi:  10.1093/rheumatology/keh658
    [57] Lim LL, Fraunfelder FW, Rosenbaum JT. Do tumor necrosis factor inhibitors cause uveitis? A registry-based study[J]. Arthritis Rheum, 2007, 56: 3248- 3252. doi:  10.1002/art.22918
    [58] Skrabl-Baumgartner A, Seidel G, Langner-Wegscheider B, et al. Drug monitoring in long-term treatment with adalimumab for juvenile idiopathic arthritis-associated uveitis[J]. Arch Dis Child, 2019, 104: 246-250. doi:  10.1136/archdischild-2018-315060
    [59] Kahn P, Weiss M, Imundo LF, et al. Favorable Response to High-Dose Infliximab for Refractory Childhood Uveitis[J]. Ophthalmology, 2006, 113: 860-864. e2. doi:  10.1016/j.ophtha.2006.01.005
    [60] Correll CK, Bullock DR, Cafferty R, et al. Safety and clinical response of weekly adalimumab in the treatment of juvenile idiopathic arthritis, pediatric chronic uveitis and other childhood rheumatic diseases[J]. Arthritis Rheumatol, 2016, 68: 501-504.
    [61] Tappeiner C, Heinz C, Ganser G, et al. Is tocilizumab an effective option for treatment of refractory uveitis associated with juvenile idiopathic arthritis?[J]. J Rheumatol, 2012, 39: 1294-1295.
    [62] Tappeiner C, Mesquida M, Adán A, et al. Evidence for tocilizumab as a treatment option in refractory uveitis associa-ted with juvenile idiopathic arthritis[J]. J Rheumatol, 2016, 43: 2183-2188. doi:  10.3899/jrheum.160231
    [63] Burmester GR, Rubbert-Roth A, Cantagrel A, et al. A randomised, double-blind, parallel-group study of the safety and efficacy of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional disease-modifying antirheumatic drugs in patients with moderate to severe rheumatoid art[J]. Ann Rheum Dis, 2014, 73: 69-74. doi:  10.1136/annrheumdis-2013-203523
    [64] Quesada-Masachs E, Caballero CM. Subcutaneous tocilizumab may be less effective than intravenous tocilizumab in the treatment of juvenile idiopathic arthritis-Associated uveitis[J]. J Rheumatol, 2017, 44: 260-261. doi:  10.3899/jrheum.160908
    [65] Adán A, Moll-Udina A, Ramirez J, et al. Subcutaneous Tocilizumab for Cystoid Macular Edema Secondary to Juvenile Idiopathic Arthritis (JIA)-associated Uveitis: A Case Report[J]. Ocul Immunol Inflamm, 2021, 29: 6-8. doi:  10.1080/09273948.2019.1644350
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  • 收稿日期:  2023-02-19
  • 录用日期:  2023-03-15
  • 网络出版日期:  2023-03-19
  • 刊出日期:  2023-03-30

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