Abstract: Chronic pain is characterized by a high incidence and persistent, challenging recovery. It not only significantly troubles patients but also poses substantial challenges for clinical treatment. Digital therapeutics (DTx), an emerging evidence-based therapeutic approach by software programs, provides individualized disease management strategies for patients through digital networks. DTx enhances treatment adherence and facilitates data collection, which can be used as a monotherapy or in combination with other therapies. This review aims to summarize the progress of DTx application in the diagnosis and treatment of chronic pain, with the goal of providing valuable insights for the clinical management of chronic pain.