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在线自适应放疗技术治疗局部进展期宫颈癌一例

王光宇 晏俊芳 汪之群 张宇 孙显松 李晶 李文博 杨波 张福泉

王光宇, 晏俊芳, 汪之群, 张宇, 孙显松, 李晶, 李文博, 杨波, 张福泉. 在线自适应放疗技术治疗局部进展期宫颈癌一例[J]. 协和医学杂志, 2023, 14(5): 1101-1105. doi: 10.12290/xhyxzz.2023-0076
引用本文: 王光宇, 晏俊芳, 汪之群, 张宇, 孙显松, 李晶, 李文博, 杨波, 张福泉. 在线自适应放疗技术治疗局部进展期宫颈癌一例[J]. 协和医学杂志, 2023, 14(5): 1101-1105. doi: 10.12290/xhyxzz.2023-0076
WANG Guangyu, YAN Junfang, WANG Zhiqun, ZHANG Yu, SUN Xiansong, LI Jing, LI Wenbo, YANG Bo, ZHANG Fuquan. Locally Advanced Cervical Cancer Treated with Online Adaptive Radiotherapy: A Case Report[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 1101-1105. doi: 10.12290/xhyxzz.2023-0076
Citation: WANG Guangyu, YAN Junfang, WANG Zhiqun, ZHANG Yu, SUN Xiansong, LI Jing, LI Wenbo, YANG Bo, ZHANG Fuquan. Locally Advanced Cervical Cancer Treated with Online Adaptive Radiotherapy: A Case Report[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 1101-1105. doi: 10.12290/xhyxzz.2023-0076

在线自适应放疗技术治疗局部进展期宫颈癌一例

doi: 10.12290/xhyxzz.2023-0076
基金项目: 

国家重点研发计划 2022YFC2407100

国家重点研发计划 2022YFC2407101

国家重点研发计划 2022YFC2407102

详细信息
    通讯作者:

    晏俊芳, E-mail: yanjunfang@pumch.cn

  • 中图分类号: R737.3; R815

Locally Advanced Cervical Cancer Treated with Online Adaptive Radiotherapy: A Case Report

Funds: 

National Key Research and Development Program of China 2022YFC2407100

National Key Research and Development Program of China 2022YFC2407101

National Key Research and Development Program of China 2022YFC2407102

More Information
  • 摘要: 在线自适应放疗技术是继调强放疗技术后的革命性进步,目前国内首个基于迭代锥形束CT(iterative cone beam computed tomography,iCBCT)的人工智能在线自适应放疗平台在北京协和医院被应用于临床治疗。本文报道北京协和医院放射治疗科首次采用基于iCBCT的在线自适应放疗技术治疗局部进展期宫颈癌患者1例,治疗后患者症状达到临床完全缓解且仅发生1级下消化道不良反应(腹泻),未出现1级及以上的血液学、泌尿生殖系统及其他放疗相关不良反应。本文就该患者的临床诊疗过程及随访展开讨论,以期为后续大规模应用该技术提供临床借鉴。
    作者贡献:王光宇负责数据收集、整理及论文撰写;汪之群、李文博、杨波负责放疗计划设计;张宇、孙显松负责放疗计划执行;李晶负责放疗设备的技术支持;晏俊芳、张福泉负责研究设计与论文修订。
    利益冲突:所有作者均声明不存在利益冲突
    注:本研究发表已获得患者知情同意。
  • 图  1  患者放疗前盆腔MRI图像示宫颈环周略长T2高信号(箭头)

    图  2  患者在线自适应放疗整体治疗流程

    iCBCI: 迭代锥形束CT;OAR: 危及器官

    图  3  患者放疗后盆腔MRI图像

    A.放疗26次后宫颈环周略长T2高信号(箭头);B.放疗后1个月宫颈T2信号较前降低(箭头);C.放疗后4个月宫颈未见异常信号

  • [1] Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries[J]. CA Cancer J Clin, 2021, 71: 209-249. doi:  10.3322/caac.21660
    [2] Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68: 394-424. doi:  10.3322/caac.21492
    [3] Naga Ch P, Gurram L, Chopra S, et al. The management of locally advanced cervical cancer[J]. Curr Opin Oncol, 2018, 30: 323-329. doi:  10.1097/CCO.0000000000000471
    [4] Klopp AH, Yeung AR, Deshmukh S, et al. Patient-Reported Toxicity During Pelvic Intensity-Modulated Radiation Therapy: NRG Oncology-RTOG 1203[J]. J Clin Oncol, 2018, 36: 2538-2544. doi:  10.1200/JCO.2017.77.4273
    [5] Chopra S, Gupta S, Kannan S, et al. Late Toxicity After Adjuvant Conventional Radiation Versus Image-Guided Intensity-Modulated Radiotherapy for Cervical Cancer (PARCER): A Randomized Controlled Trial[J]. J Clin Oncol, 2021, 39: 3682-3692. doi:  10.1200/JCO.20.02530
    [6] Gandhi AK, Sharma DN, Rath GK, et al. Early clinical outcomes and toxicity of intensity modulated versus conventional pelvic radiation therapy for locally advanced cervix carcinoma: a prospective randomized study[J]. Int J Radiat Oncol Biol Phys, 2013, 87: 542-548. doi:  10.1016/j.ijrobp.2013.06.2059
    [7] Jadon R, Pembroke CA, Hanna CL, et al. A systematic review of organ motion and image-guided strategies in external beam radiotherapy for cervical cancer[J]. Clin Oncol (R Coll Radiol), 2014, 26: 185-196. doi:  10.1016/j.clon.2013.11.031
    [8] Barazzuol L, Coppes RP, van Luijk P. Prevention and treatment of radiotherapy-induced side effects[J]. Mol Oncol, 2020, 14: 1538-1554. doi:  10.1002/1878-0261.12750
    [9] Hale MF. Radiation enteritis: from diagnosis to management[J]. Curr Opin Gastroenterol, 2020, 36: 208-214. doi:  10.1097/MOG.0000000000000632
    [10] Åström LM, Behrens CP, Storm KS, et al. Online adaptive radiotherapy of anal cancer: Normal tissue sparing, target propagation methods, and first clinical experience[J]. Radiother Oncol, 2022, 176: 92-98. doi:  10.1016/j.radonc.2022.09.015
    [11] Christiansen RL, Dysager L, Hansen CR, et al. Online adaptive radiotherapy potentially reduces toxicity for high-risk prostate cancer treatment[J]. Radiother Oncol, 2022, 167: 165-171. doi:  10.1016/j.radonc.2021.12.013
    [12] Kerkhof EM, Raaymakers BW, van der Heide UA, et al. Online MRI guidance for healthy tissue sparing in patients with cervical cancer: an IMRT planning study[J]. Radiother Oncol, 2008, 88: 241-249. doi:  10.1016/j.radonc.2008.04.009
    [13] Bertelsen AS, Schytte T, Møller PK, et al. First clinical experiences with a high field 1.5 T MR linac[J]. Acta Oncol, 2019, 58: 1352-1357. doi:  10.1080/0284186X.2019.1627417
    [14] Alongi F, Rigo M, Figlia V, et al. 1.5 T MR-guided and daily adapted SBRT for prostate cancer: feasibility, preliminary clinical tolerability, quality of life and patient-reported outcomes during treatment[J]. Radiat Oncol, 2020, 15: 69. doi:  10.1186/s13014-020-01510-w
    [15] de Jong R, Visser J, van Wieringen N, et al. Feasibility of Conebeam CT-based online adaptive radiotherapy for neoadjuvant treatment of rectal cancer[J]. Radiat Oncol, 2021, 16: 136. doi:  10.1186/s13014-021-01866-7
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出版历程
  • 收稿日期:  2023-02-13
  • 录用日期:  2023-03-28
  • 网络出版日期:  2023-08-04
  • 刊出日期:  2023-09-30

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