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Relationship Between Vitamin D and Metabolic Associated Fatty Liver Disease and Its Mechanism
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摘要:
代谢相关脂肪性肝病（ metabolic associated fatty liver disease，MAFLD）由非酒精性脂肪性肝病更名而来。关于MAFLD的发病机制，目前普遍接受“多重打击”理论，其涉及遗传和环境因素的相互作用，包括胰岛素抵抗、脂质紊乱、氧化应激、肠道微生物群等。然而，目前尚无获批治疗MAFLD的特效药物。近年来，研究发现维生素D缺乏参与了代谢综合征和脂肪肝的发生，但其具体作用机制尚未明确，可能通过影响肝脏脂质代谢、胰岛素敏感性及促炎细胞因子水平进而导致MAFLD的发生，还可通过参与免疫功能调节、基因调控而参与MAFLD的发生。此外，补充维生素D通过肠-肝轴调节肠道微生物群和胆汁酸代谢，可缓解脂肪肝的进展。基于此，本文就维生素D与MAFLD之间的关系进行阐述，并揭示维生素D在MAFLD发病中的潜在机制，为MAFLD的治疗提供临床思路。
Abstract:Metabolic associated fatty liver disease (MAFLD) was renamed from the nonalcoholic fatty liver disease (NAFLD). At present， about the pathogenesis of MAFLD， people generally accept the "multiple strike" theory， which involves the interaction of genetic and environmental factors. These attacks include insulin resistance， lipid disorder， oxidative stress， intestinal microbiota， etc. However， there is no approved drug for MAFLD. Recent studies have found that vitamin D is involved in many metabolic processes， which may be involved in the development of MAFLD by influencing liver lipid metabolism， promoting insulin resistance and inflammatory response， participating in immune regulation， gene regulation and maintaining intestinal homeostasis. Therefore， this article summarizes the relationship between vitamin D and MAFLD， reveals the potential mechanism of vitamin D in the pathogenesis of MAFLD， and provides clinical ideas for the treatment of MAFLD.
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Key words:
- vitamin D /
- metabolic associated fatty liver disease /
- vitamin D receptor
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