间充质干细胞对脑缺血性再灌注损伤的保护作用

汪杰; 李湘民

doi:10.12290/xhyxzz.2022-0734

间充质干细胞对脑缺血性再灌注损伤的保护作用

doi: 10.12290/xhyxzz.2022-0734

汪杰,
李湘民^,

中南大学湘雅医院急诊科, 长沙 410008

基金项目:

湖南省自然科学基金 2022JJ30938

详细信息

通讯作者:
李湘民, E-mail: lxm8229@csu.edu.cn

中图分类号: R743;R459.7
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- 文章访问数: 88
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- PDF下载量: 18
- 被引次数: 0
出版历程
- 收稿日期: 2022-12-30
- 录用日期: 2023-03-24
- 网络出版日期: 2023-03-29
- 刊出日期: 2023-05-30

Protective Effect of Mesenchymal Stem Cells on Cerebral Ischemic Reperfusion Injury

WANG Jie,
LI Xiangmin^,

Department of Emergency, Xiangya Hospital, Central South University, Changsha 410008, China

Funds:

Natural Science Foundation of Hunan Province 2022JJ30938

More Information

Corresponding author: LI Xiangmin, E-mail: lxm8229@csu.edu.cn

摘要

摘要: 脑缺血再灌注损伤是神经系统疾病患者预后欠佳的主要原因之一, 也是目前导致患者瘫痪的重要原因, 多见于心脏骤停、脑出血、脑梗死、脑卒中等疾病, 其经典的病理生理机制主要包括氧化应激、炎症反应、钙超载、一氧化氮损伤以及兴奋性氨基酸毒性作用等。随着医疗技术的发展, 脑缺血再灌注损伤的治疗方案不断完善, 然而更加精准有效的治疗方案仍在不断探索中。间充质干细胞(mesenchymal stem cells, MSCs)是一种多能干细胞, 存在于骨髓、肌肉、脂肪等组织器官中。近年来, MSCs凭借其强大的分化能力、分泌能力以及良好的免疫相容性, 被用于探索治疗多种疾病。本文从病理生理机制出发, 阐述MSCs在脑缺血再灌注损伤中的保护作用, 以期为脑缺血再灌注损伤的治疗提供新思路。
- 脑缺血再灌注损伤 /
- 间充质干细胞 /
- 氧化应激 /
- 炎症反应 /
- 旁分泌
Abstract: Cerebral ischemia-reperfusion injury, one of the main reasons for poor prognosis in patients with neurological diseases, is also an important cause of paralysis. It is more common in cardiac arrest, cerebral hemorrhage, cerebral infarction and stroke. The classical pathophysiological mechanisms mainly include oxidative stress, inflammatory response, calcium overload, nitric oxide and excitatory amino acid toxicity. With the development of medical technology, the treatment of cerebral ischemia-reperfusion injury has been improved. However, there is still an urgent need to explore more accurate and effective treatments. Mesenchymal stem cells (MSCs) are multipotential stem cells in bone marrow, muscle, fat and other tissues and organs. In recent years, MSCs have been explored in the treatment of various diseases because of their strong differentiation ability, secretion ability and good immunocompatibility. This paper describes the pathophysiological process of cerebral ischemia-reperfusion injury, and summarizes the role of MSCs in cerebral ischemia-reperfusion injury from the perspective of pathophysiological mechanism, in order to provide a new idea for the treatment of cerebral ischemia-reperfusion injury.
- cerebral ischemia-reperfusion injury /
- mesenchymal stem cells /
- oxidative stress /
- inflammatory response /
- paracrine
注释:

作者贡献：汪杰、李湘民负责论文构思和框架构建；汪杰负责文献检索及论文撰写；李湘民负责论文指导及修订。

利益冲突：所有作者均声明不存在利益冲突

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间充质干细胞对脑缺血性再灌注损伤的保护作用

doi: 10.12290/xhyxzz.2022-0734

通讯作者:
李湘民, E-mail: lxm8229@csu.edu.cn

计量

Protective Effect of Mesenchymal Stem Cells on Cerebral Ischemic Reperfusion Injury

Corresponding author: LI Xiangmin, E-mail: lxm8229@csu.edu.cn

计量

目录

留言板

间充质干细胞对脑缺血性再灌注损伤的保护作用

doi: 10.12290/xhyxzz.2022-0734

通讯作者: 李湘民, E-mail: lxm8229@csu.edu.cn

计量

出版历程

Protective Effect of Mesenchymal Stem Cells on Cerebral Ischemic Reperfusion Injury

Corresponding author: LI Xiangmin, E-mail: lxm8229@csu.edu.cn

计量

出版历程

目录

通讯作者:
李湘民, E-mail: lxm8229@csu.edu.cn