Abstract: Neuromyelitis optica spectrum disorders(NMOSD), an inflammatory demyelinating disease of central nervous system, is characterized by optic neuritis, longitudinally extensive transverse myelitis, and neuropathic pain. Given the lack of mature animal models, the mechanism of neuropathic pain in NMOSD is still unclear, although some studies have reported neuropathic pain in NMOSD models. It is therefore necessary to build a reliable and feasible animal model of NMOSD related neuropathic pain, in order to provide scientific support for the mechanism and the mining of therapeutic targets. This article reviews the research progress of the establishment of NMOSD-related neuropathic pain animal models and their applications, and provides a reference for the establishment of ideal NMOSD neuropathic pain animal models.