胃内微生态在胃癌发生发展过程中的作用机制

Research Progress on the Mechanism of Gastric Microecology in the Development of Gastric Cancer

摘要: 微生态已被证明与消化系统疾病密切相关，而关乎胃内微生态的研究大多以幽门螺杆菌为重点。随着微阵列及基因检测技术的发展，除幽门螺杆菌外，越来越多的菌属如放线菌、厚壁菌、梭状菌等被发现，且被证明与胃癌的发生发展过程密切相关。本文通过回顾相关文献，对胃内微生态在胃癌发生发展过程中的作用及可能机制展开综述，以期为临床诊疗提供参考。

Abstract: Microecology has been shown to be closely related to digestive diseases, and most of the research on gastric microecology has focused on Helicobacter pylori. With the development of microarray and gene detection technology, in addition to Helicobacter pylori, more and more bacteria genera have been discovered, such as Actinomyces, Firmicute and Clostridium. These bacteria genera and their abundance changes have also been proved to be closely related to the occurrence and development of gastric cancer. In this paper, the role and possible mechanism of gastric microecology in the occurrence and development of gastric cancer are reviewed, with the hope of providing reference for clinical diagnosis and treatment.