Abstract: Subtype classification of primary aldosteronism is important but challenging. Increasing evidence has shown that ⁶⁸Ga-Pentixafor PET/CT imaging which targets CXCR4 is beneficial to the subtype classification of primary aldosteronism. Based on all the available evidence, and after in-depth discussion of a group of multi-disciplinary experts, a consensus has been established, which covers imaging technology, interpretation of results of CXCR4 imaging, and the guidance to the choice of the treatment and prognosisevaluation. The consensus is helpful for standardizing ⁶⁸Ga-Pentixafor PET/CT imaging and promoting a better diagnosis procedure in primary aldosteronism.