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Ⅰ型自身免疫性胰腺炎发病机制及研究进展

刘屹霄,  杨莹韵,  杨爱明

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刘屹霄, 杨莹韵, 杨爱明. Ⅰ型自身免疫性胰腺炎发病机制及研究进展[J]. 协和医学杂志. doi: 10.12290/xhyxzz.2022-0517
引用本文: 刘屹霄, 杨莹韵, 杨爱明. Ⅰ型自身免疫性胰腺炎发病机制及研究进展[J]. 协和医学杂志. doi: 10.12290/xhyxzz.2022-0517
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LIU Yixiao, YANG Yingyun, YANG Aiming. Advances in the Pathogenesis of Type Ⅰ Autoimmune Pancreatitis[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2022-0517
Citation: LIU Yixiao, YANG Yingyun, YANG Aiming. Advances in the Pathogenesis of Type Ⅰ Autoimmune Pancreatitis[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2022-0517
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Ⅰ型自身免疫性胰腺炎发病机制及研究进展

doi: 10.12290/xhyxzz.2022-0517

  • 中国医学科学院北京协和医院消化内科, 北京 100730

基金项目: 

国家自然科学基金（82073184）；中央高水平医院临床科研业务费（2022-PUMCH-B-024）；国家级大学生创新创业训练计划（202210023002）

详细信息
    通讯作者:

    杨爱明,E-mail:yangaiming@medmail.com.cn

  • 中图分类号: R657.5+1;R593.2

Advances in the Pathogenesis of Type Ⅰ Autoimmune Pancreatitis

  • Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing 100730, China

Funds: 

National Natural Science Foundation of China (82073184)

    摘要
  • 摘要: Ⅰ型自身免疫性胰腺炎（autoimmune pancreatitis，AIP）是一种以炎症和纤维化为主的胰腺炎，属于IgG4相关性疾病。目前关于Ⅰ型AIP的发病机制认识尚浅，普遍认为其发病是遗传、环境、免疫等多方面因素的综合结果。近年来，在Ⅰ型AIP发病的细胞和分子机制方面取得了诸多进展，本文主要从免疫学角度阐述其发病机制及研究进展。
    Abstract: Type Ⅰ autoimmune pancreatitis (AIP) is a type of pancreatitis with a predominantly inflammatory and fibrotic nature and is an IgG4-related disease. The pathogenesis of type Ⅰ AIP is still poorly understood， and it is generally believed that its pathogenesis is the result of a combination of genetic， environmental， and immune factors. In recent years， many advances have been made in the cellular and molecular mechanisms of the pathogenesis of type Ⅰ AIP， and this article mainly reviews the understanding and research progress of the pathogenesis of this disease from the immunological perspective in recent years.
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出版历程
  • 收稿日期:  2022-09-10
  • 网络出版日期:  2022-11-16

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