Abstract: Crohn's disease（ CD） is a kind of inflammatory bowel disease, and its incidence rate is increasing year by year. Mesenteric creeping fat is a special sign of CD， which is closely related to intestinal inflammation and stenosis of CD. It is a research hotspot in recent years. The formation mechanism of mesenteric creeping fat may be related to the migration of adipocytes and the translocation of intestinal microbiota. However, at present, there is no standard imaging method to evaluate mesenteric fat entrapment. MRI, CT and US are commonly used imaging evaluation methods for CD， which can show the sign of creeping fat, and evaluate the inflammation of intestinal wall and intestinal stenosis. However, the relationship between mesenteric creeping fat and inflammatory activity, stenosis and prognosis of CD remains to be further studied. The purpose of this review is to introduce the pathogenesis and clinical significance of mesenteric creeping fat, as well as the evaluation indicators of different imaging methods, and to further explore the relationship between mesenteric creeping fat and CD inflammatory activity and stenosis.