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ThinPrep玻片扫描分析影像系统在子宫颈细胞学中的临床应用

孔令华 肖晓萍 万茹 向阳

孔令华, 肖晓萍, 万茹, 向阳. ThinPrep玻片扫描分析影像系统在子宫颈细胞学中的临床应用[J]. 协和医学杂志. doi: 10.12290/xhyxzz.2022-0221
引用本文: 孔令华, 肖晓萍, 万茹, 向阳. ThinPrep玻片扫描分析影像系统在子宫颈细胞学中的临床应用[J]. 协和医学杂志. doi: 10.12290/xhyxzz.2022-0221
KONG Linghua, XIAO Xiaoping, WAN Ru, XIANG Yang. The Application of ThinPrep Imaging System in Clinical Application of Cervical Cytology[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2022-0221
Citation: KONG Linghua, XIAO Xiaoping, WAN Ru, XIANG Yang. The Application of ThinPrep Imaging System in Clinical Application of Cervical Cytology[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2022-0221

ThinPrep玻片扫描分析影像系统在子宫颈细胞学中的临床应用

doi: 10.12290/xhyxzz.2022-0221
详细信息
    通讯作者:

    向阳,E-mail:xiangy@pumch.cn

  • 中图分类号: R361+.3;R73

The Application of ThinPrep Imaging System in Clinical Application of Cervical Cytology

  • 摘要: 目的 探讨ThinPrep玻片扫描分析影像系统(ThinPrep Imaging System,TIS)在子宫颈细胞学中的临床应用效果。 方法 回顾性分析中国医学科学院北京协和医院妇产科门诊2016年12月至2017年5月宫颈液基细胞学(Liquid-based cytology,LBC)样本人工阅片结果以及2017年12月至2018年5月LBC样本TIS辅助阅片结果,分析两种阅片方式的异常细胞学检出率,并随访异常细胞学的组织学活检结果以及异常鳞状上皮细胞标本的高危型人乳头瘤病毒(high risk-human papilloma virus,Hr-HPV)阳性率。 结果 共计人工阅片17407例,TIS辅助阅片16564例。与人工阅片相比,TIS辅助阅片的总体异常细胞学检出率显著提高(15.21%比9.58%,P<0.001),其中非典型鳞状上皮细胞、不除外高度鳞状上皮内病变的非典型鳞状上皮细胞、低度鳞状上皮内病变、高度鳞状上皮内病变、不典型腺细胞和腺癌的检出率分别提高了2.77%、0.28%、2.08%、0.35%、0.08%和0.08%,差异均具有统计学意义(P均<0.05)。对细胞学异常患者进行组织学随访,TIS辅助阅片比人工阅片的组织学符合率有所提升,但差异均无统计学意义(P均>0.05)。TIS辅助阅片异常腺细胞的检出数量是人工阅片的2倍(55例比27例),经组织学证实的腺癌数量是人工阅片的2.3倍(37例比16例)。TIS辅助阅片与人工阅片鳞状上皮细胞异常患者的Hr-HPV阳性率均无统计学差异(P均>0.05)。同时,TIS辅助阅片时间缩短,阅片效率可提升33%~50%。 结论 使用TIS辅助阅片不仅显著提高了宫颈LBC异常检出率和工作效率,组织学符合率亦有所提升,值得临床进一步推广应用。
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出版历程
  • 收稿日期:  2022-04-20
  • 录用日期:  2022-05-31
  • 网络出版日期:  2022-06-23

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