Progress of Controlled Drug Delivery Systems for Local Anesthesia
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摘要: 减少用药次数、延长术后镇痛时间是临床局部麻醉的重要需求。然而,无论是当前临床使用的局部麻醉药物,还是生物毒素类潜在新型麻醉药物均存在时效较短的问题。利用脂质体、聚合物微球等药物载体装载局部麻醉药物进行控释,可以实现药物的长效、按需释放,从而满足上述临床需求。本文简要概述可用于局部麻醉药物控释的药物载体,并介绍具有代表性的药物控释体系的设计、功能及其用于局部麻醉的最新研究进展,同时对此研究领域进行展望。Abstract: Reducing the drug doses and prolonging the postoperative analgesia time are important requirements of clinical local anesthesia. However, All local anesthetic drugs currently used in the clinic and potentially new anesthetic drugs such as biological toxins exhibit limited pharmaceutical effect. Biomaterials such as liposomes and polymeric microspheres can be designed to load local anesthetic drugs to achieve a prolonged duration and on-demand drug release, accordingly satisfying clinical needs. In this review, we briefly summarized the recent developments in the design of drug delivery systems for controlled release of local anesthetic drugs, and introduced the design concept, the function of several representative controlled-release drug systems, and their applications in local anesthesia. We discussed the challenges and future perspectives for biomaterial innovations in this field.
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Key words:
- drug delivery systems /
- local anesthesia /
- sustained release /
- responsive release /
- long-term efficacy
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