Abstract: Difficult airway is one of the common clinical problems in anesthesia management, which is closely related to the safety and quality of anesthesia. Standardized the management of patients with difficult airway is an important part of anesthesia. As many international academic organizations have successively issued a number of practical guidelines or expert consensuses, the treatment of difficult airway by medical staff is constantly renewed. In January 2022, the 2022 American Society of Anesthesiologists Practice Guidelines for Management of the Difficult Airway was released, which updated the content from the evaluation, preparation, management and other aspects of difficult airway. With a view to providing clinical reference for the standardized management of difficult airway, this paper makes a detailed interpretation of the key points of the guideline.