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从我国系统性红斑狼疮的诊治现状寻找可能的解决方案——来自《中国系统性红斑狼疮发展报告2020》的启示

田新平 李梦涛 曾小峰

田新平, 李梦涛, 曾小峰. 从我国系统性红斑狼疮的诊治现状寻找可能的解决方案——来自《中国系统性红斑狼疮发展报告2020》的启示[J]. 协和医学杂志, 2022, 13(2): 169-173. doi: 10.12290/xhyxzz.2022-0020
引用本文: 田新平, 李梦涛, 曾小峰. 从我国系统性红斑狼疮的诊治现状寻找可能的解决方案——来自《中国系统性红斑狼疮发展报告2020》的启示[J]. 协和医学杂志, 2022, 13(2): 169-173. doi: 10.12290/xhyxzz.2022-0020
TIAN Xinping, LI Mengtao, ZENG Xiaofeng. Finding Possible Solutions for the Management of Systemic Lupus Erythematosus from the Current Situation and Challenges in China[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(2): 169-173. doi: 10.12290/xhyxzz.2022-0020
Citation: TIAN Xinping, LI Mengtao, ZENG Xiaofeng. Finding Possible Solutions for the Management of Systemic Lupus Erythematosus from the Current Situation and Challenges in China[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(2): 169-173. doi: 10.12290/xhyxzz.2022-0020

从我国系统性红斑狼疮的诊治现状寻找可能的解决方案——来自《中国系统性红斑狼疮发展报告2020》的启示

doi: 10.12290/xhyxzz.2022-0020
基金项目: 

国家重点研发计划 2021YFC2501301-5

北京市科学技术委员会资助项目 Z201100005520022

北京市科学技术委员会资助项目 Z201100005520023

北京市科学技术委员会资助项目 Z201100005520025

北京市科学技术委员会资助项目 Z201100005520026

北京市科学技术委员会资助项目 Z201100005520027

中国医学科学院医学与健康科技创新工程 2021-I2M-1-005

详细信息
    通讯作者:

    曾小峰,E-mail:xiaofeng.zeng@cstar.org.cn

  • 中图分类号: R593.24; R593.2

Finding Possible Solutions for the Management of Systemic Lupus Erythematosus from the Current Situation and Challenges in China

Funds: 

National Key Research and Development Program of China 2021YFC2501301-5

Beijing Municipal Science and Technology Commission Z201100005520022

Beijing Municipal Science and Technology Commission Z201100005520023

Beijing Municipal Science and Technology Commission Z201100005520025

Beijing Municipal Science and Technology Commission Z201100005520026

Beijing Municipal Science and Technology Commission Z201100005520027

CAMS Innovation Fund for Medical Sciences 2021-I2M-1-005

More Information
  • 摘要: 系统性红斑狼疮(systemic lupus erythematosus,SLE)已逐渐成为我国常见的慢性自身免疫性疾病。据估计,目前我国SLE患者约100万人,具有患者人数多、病情重、并发症发生率高、社会与经济负担重以及对生育影响大的特点。由于我国风湿免疫病学科建设起步晚,全国发展极不均衡,风湿免疫病专业从业人员在数量和质量上均不能满足SLE患者的需求,导致我国SLE诊治的规范化程度不足,患者的临床缓解率和长期存活率均低于世界发达国家。此外,由于SLE患者缺乏对疾病的正确认知,目前我国尚缺乏完善的慢病管理体系,造成SLE患者治疗依从性低、治疗效果差的现状。因此,通过覆盖全国的SLE诊治协作网,充分发挥国家皮肤与免疫疾病临床医学研究中心的引领作用,促进风湿免疫病专科发展,建立完善的慢病管理体系,充分利用国家发展风湿免疫科的相关政策,促进临床与基础研究成果的快速转化以及开展高质量的临床研究是可能的解决方案。
    作者贡献:田新平、李梦涛负责文献查阅、资料收集及论文撰写;曾小峰负责组织选题及论文审校。
    利益冲突:所有作者均声明不存在利益冲突
  • [1] Jolly M. How does quality of life of patients with systemic lupus erythematosus compare with that of other common chronic illnesses?[J]. J Rheumatol, 2005, 32: 1706-1708.
    [2] Zhu TY, Tam LS, Lee VW, et al. The impact of flare on disease costs of patients with systemic lupus erythematosus[J]. Arthritis Rheum, 2009, 61: 1159-1167. doi:  10.1002/art.24725
    [3] Zhang SQ, Han JW, Sun LD, et al. A single-nucleotide polymorphism of the TNFSF4 gene is associated with systemic lupus erythematosus in Chinese Han population[J]. Rheumatol Int, 2011, 31: 227-231. doi:  10.1007/s00296-009-1247-2
    [4] Zhang Y, Yang J, Zhang J, et al. Genome-wide search followed by replication reveals genetic interaction of CD80 and ALOX5AP associated with systemic lupus erythematosus in Asian populations[J]. Ann Rheum Dis, 2016, 75: 891-898.
    [5] Cheng YJ, Li MT, Zhao JL, et al. Chinese SLE Treatment and Research Group (CSTAR) registry: Ⅷ. Influence of socioeconomic and geographical variables on disease phenotype and activity in Chinese patients with SLE[J]. Int J Rheum Dis, 2018, 21: 716-724. doi:  10.1111/1756-185X.13057
    [6] Li M, Zhang W, Leng X, et al. Chinese SLE Treatment and Research group (CSTAR) registry: Ⅰ. Major clinical characteristics of Chinese patients with systemic lupus erythematosus[J]. Lupus, 2013, 22: 1192-1199. doi:  10.1177/0961203313499086
    [7] Zhang S, Su J, Li X, et al. Chinese SLE Treatment and Research group (CSTAR) registry: V. gender impact on Chinese patients with systemic lupus erythematosus[J]. Lupus, 2015, 24: 1267-1275. doi:  10.1177/0961203315585813
    [8] Mok CC. Epidemiology and survival of systemic lupus erythematosus in Hong Kong Chinese[J]. Lupus, 2011, 20: 767-771. doi:  10.1177/0961203310388447
    [9] Guillotin V, Bouhet A, Barnetche T, et al. Hydroxychloroquine for the prevention of fetal growth restriction and prematurity in lupus pregnancy: A systematic review and meta-analysis[J]. Joint Bone Spine, 2018, 85: 663-668. doi:  10.1016/j.jbspin.2018.03.006
    [10] Liu JT, Zhao Y, Song YJ, et al. Pregnancy in women with systemic lupus erythematosus: a retrospective study of 111 pregnancies in Chinese women[J]. J Matern Fetal Neonatal Med, 2012, 25: 261-266. doi:  10.3109/14767058.2011.572310
    [11] 霍春燕, 王丽. 系统性红斑狼疮患者服药相关知识和行为认知的调查[J]. 中华现代护理杂志, 2013, 19: 1023-1027.

    Huo CY, Wang L. Investigation of medication knowledge and behavior of systemic lupus erythematosus patients[J]. Zhonghua Xiandai Huli Zazhi, 2013, 19: 1023-1027.
    [12] 王军霞, 沙悦, 陈嘉林. 北京市东城区全科医生对系统性红斑狼疮疾病认知的在线问卷调查[J]. 中华全科医学, 2019, 18: 832-836.

    Wang JX, ShaY, Chen JL. Online questionnaire survey on know-ledge of systemic lupus erythematosus among general practitioners in Beijing Dongcheng district[J]. Zhonghua Quanke Yixue, 2019, 18: 832-836.
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出版历程
  • 收稿日期:  2022-01-12
  • 录用日期:  2022-01-18
  • 网络出版日期:  2022-01-18
  • 刊出日期:  2022-03-30

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