Abstract: Sepsis is a major cause of death world wide. Evidence-based SSC guidelines promoted the global medical staffs' awareness of sepsis and septic shock, strengthened the understanding of the occurrence and development, and provided a common ground for all clinicians. SSC guidelines are the premise of implementing "personalized"therapy, but management that strictly adheres to guidelines may not necessarily be the best option for each patient.Personalized management needs quantitative intervention according to the patient's pathophysiological characteristics and individual response. In this article, we will describe the correlation between "personalized" therapy and guidelines through the recommendations of 2021 SSC guidelines, and expound on how to implement personalized therapy according to clinical guidelines.