Abstract: Peptide receptor radionuclide therapy (PRRT) is one of the advanced therapies for neuroendocrine neoplasms (NENs), which can relieve the symptoms and improve the quality of life of patients with NENs with good tolerance to the treatment.However, since this treatment method has just started in China, how to implement standardized, efficient and high-quality nursing services for patients undergoing PRRT is still worth discussing. By referring to related international guidelines and clinical nursing standards, and combining our experience in the treatment of NENs using ¹⁷⁷Lu-DOTATATE, we proposed the key nursing points during the treatment process, and elaborated how to prevent common adverse reactions and undergo psychological intervention, in hope of the related personnel being able to provide more safe treatment and to improve nursing security.