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胰岛素样生长因子2在膀胱尿路上皮癌诊断中的价值

杨庭楷 文进 纪志刚

杨庭楷, 文进, 纪志刚. 胰岛素样生长因子2在膀胱尿路上皮癌诊断中的价值[J]. 协和医学杂志. doi: 10.12290/xhyxzz.2021-0446
引用本文: 杨庭楷, 文进, 纪志刚. 胰岛素样生长因子2在膀胱尿路上皮癌诊断中的价值[J]. 协和医学杂志. doi: 10.12290/xhyxzz.2021-0446
YANG Tingkai, WEN Jin, JI Zhigang. The Value of Insulin-like Growth Factor in Urinary Exosomes of Bladder Urothelial Carcinoma[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2021-0446
Citation: YANG Tingkai, WEN Jin, JI Zhigang. The Value of Insulin-like Growth Factor in Urinary Exosomes of Bladder Urothelial Carcinoma[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2021-0446

胰岛素样生长因子2在膀胱尿路上皮癌诊断中的价值

doi: 10.12290/xhyxzz.2021-0446
基金项目: 

中国医学科学院中央级公益性科研院所基本科研业务费临床与转化医学研究基金(2019XK320027);外国文教专家项目管理基金(G20190001645)

详细信息
    通讯作者:

    文进 电话:010-69152520 E-mail:wjpumch@163.com

    纪志刚 电话:010-69152520 E-mail:jzgjxmc@163.com

  • 中图分类号: R737.14

The Value of Insulin-like Growth Factor in Urinary Exosomes of Bladder Urothelial Carcinoma

  • 摘要:

        目的     探讨尿液外泌体中胰岛素样生长因子2(insulin-like growth factor-2, IGF2)在膀胱尿路上皮癌诊断中的价值。     方法     选取北京协和医院2020年9月至12月诊治的膀胱尿路上皮癌患者作为试验组,同期非尿路上皮癌患者为对照组。采用荧光RT-PCR法检测样本尿液外泌体中IGF2表达水平。以膀胱镜检查或经尿道膀胱肿瘤切除术病理检查结果为金标准,计算尿液外泌体中IGF2表达水平以及诊断膀胱尿路上皮癌的灵敏度、特异度、阳性似然比和阴性似然比。     结果     共纳入尿路上皮癌患者35例,平均年龄(65.43±12.22)岁;非尿路上皮癌患者60例,平均年龄(51.68±13.07)岁。尿液外泌体中IGF2诊断膀胱尿路上皮癌的灵敏度为71.4%(95% CI:53.5%~84.8%),特异度为90%(95% CI:78.8%~95.9%),阳性似然比为7.14(95% CI:3.25~15.7),阴性似然比为0.32(95% CI:0.19~0.54)。     结论     尿液外泌体中IGF2有望作为膀胱尿路上皮癌的初筛指标。

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出版历程
  • 收稿日期:  2021-06-03
  • 网络出版日期:  2021-07-21

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