雌激素对呼吸道病毒感染的保护作用

陈筱涵; 郁琦

doi:10.12290/xhyxzz.20200202

雌激素对呼吸道病毒感染的保护作用

doi: 10.12290/xhyxzz.20200202

陈筱涵,
郁琦^,

中国医学科学院北京协和医学院北京协和医院妇产科，北京 100730

基金项目:

国家重点研发计划 2018YFC1002105

详细信息

通讯作者:
郁琦电话：010-69158621，E-mail：yuqimd@163.com

中图分类号: R71; R18
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- 文章访问数: 94
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- PDF下载量: 22
- 被引次数: 0
出版历程
- 收稿日期: 2020-07-28
- 录用日期: 2020-11-10
- 网络出版日期: 2021-01-04
- 刊出日期: 2021-05-30

Protective Effect of Estrogen on Infection of Respiratory Virus

CHEN Xiao-han,
YU Qi^,

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds:

National Key Research and Development Program 2018YFC1002105

More Information

Corresponding author: YU Qi Tel: 86-10-69158621, E-mail: yuqimd@163.com

摘要

摘要: 雌激素是一种多功能甾体类激素，不仅对女性生殖系统，且对内分泌、心血管、代谢系统等均具有明显作用。雌激素对多种肺部疾病具有潜在治疗价值，雌激素受体信号转导在呼吸道病毒感染过程中，参与机体固有免疫、适应性免疫、组织修复过程。动物实验证实，雌激素可以降低炎性因子水平，抑制炎症反应，降低病毒滴度等，从而提高呼吸道病毒感染小鼠的存活率。本文探讨雌激素对于呼吸道病毒感染的保护作用及其机制。
- 呼吸道感染 /
- 病毒 /
- 雌激素 /
- 保护机制
Abstract: Estrogen is a multi-functional steroid hormone, which affects not only the female reproductive system, but also endocrine, cardiovascular, and metabolic systems. Estrogen has a potential therapeutic effect on a variety of lung diseases, and estrogen-receptor signaling plays a key role in the innate immunity, adaptive immunity and tissue repair in the course of infection of respiratory virus. Animal experiments have proved that estrogen therapy can reduce inflammatory factors, inhibit inflammatory response, reduce viral titer and so on, so as to improve the survival rate of mice infected with respiratory virus. In this paper, the protective effect of estrogen on the infection of respiratory virus and related mechanisms were reviewed.
- respiratory infection /
- virus /
- estrogen /
- protective mechanism
注释:

作者贡献：陈筱涵负责资料收集、论文撰写; 郁琦负责选题构思、论文修订。

利益冲突： 无

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参考文献(41)

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雌激素对呼吸道病毒感染的保护作用

doi: 10.12290/xhyxzz.20200202

通讯作者:
郁琦电话：010-69158621，E-mail：yuqimd@163.com

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Protective Effect of Estrogen on Infection of Respiratory Virus

Corresponding author: YU Qi Tel: 86-10-69158621, E-mail: yuqimd@163.com

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留言板

雌激素对呼吸道病毒感染的保护作用

doi: 10.12290/xhyxzz.20200202

通讯作者: 郁琦 电话：010-69158621，E-mail：yuqimd@163.com

计量

出版历程

Protective Effect of Estrogen on Infection of Respiratory Virus

Corresponding author: YU Qi Tel: 86-10-69158621, E-mail: yuqimd@163.com

计量

出版历程

目录

通讯作者:
郁琦电话：010-69158621，E-mail：yuqimd@163.com