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肌力下降、呼吸衰竭、心力衰竭、抗线粒体抗体阳性——罕见炎性肌病的不典型表现

路菲 张宁 康琳 孙晓红 田然 郭潇潇 留永健 张文 彭琳一 苏童 曹剑 王怡宁 钱敏 曹宇泽 杨璐 刘跃华 张路 赵肖奕 冷泠

路菲, 张宁, 康琳, 孙晓红, 田然, 郭潇潇, 留永健, 张文, 彭琳一, 苏童, 曹剑, 王怡宁, 钱敏, 曹宇泽, 杨璐, 刘跃华, 张路, 赵肖奕, 冷泠. 肌力下降、呼吸衰竭、心力衰竭、抗线粒体抗体阳性——罕见炎性肌病的不典型表现[J]. 协和医学杂志. doi: 10.12290/xhyxzz.2020-0109
引用本文: 路菲, 张宁, 康琳, 孙晓红, 田然, 郭潇潇, 留永健, 张文, 彭琳一, 苏童, 曹剑, 王怡宁, 钱敏, 曹宇泽, 杨璐, 刘跃华, 张路, 赵肖奕, 冷泠. 肌力下降、呼吸衰竭、心力衰竭、抗线粒体抗体阳性——罕见炎性肌病的不典型表现[J]. 协和医学杂志. doi: 10.12290/xhyxzz.2020-0109
LU Fei, ZHANG Ning, KANG Lin, SUN Xiaohong, TIAN Ran, GUO Xiaoxiao, LIU Yongjian, ZHANG Wen, PENG Linyi, SU Tong, CAO Jian, WANG Yining, QIAN Min, CAO Yuze, YANG Lu, LIU Yuehua, ZHANG Lu, ZHAO Xiaoyi, LENG Ling. Decreased Muscle Strength, Type 2 Respiratory Failure, Heart Failure, with Positive Anti-mitochondrial Antibodies—Rare Atypical Manifestations of Inflammatory Myopathy[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2020-0109
Citation: LU Fei, ZHANG Ning, KANG Lin, SUN Xiaohong, TIAN Ran, GUO Xiaoxiao, LIU Yongjian, ZHANG Wen, PENG Linyi, SU Tong, CAO Jian, WANG Yining, QIAN Min, CAO Yuze, YANG Lu, LIU Yuehua, ZHANG Lu, ZHAO Xiaoyi, LENG Ling. Decreased Muscle Strength, Type 2 Respiratory Failure, Heart Failure, with Positive Anti-mitochondrial Antibodies—Rare Atypical Manifestations of Inflammatory Myopathy[J]. Medical Journal of Peking Union Medical College Hospital. doi: 10.12290/xhyxzz.2020-0109

肌力下降、呼吸衰竭、心力衰竭、抗线粒体抗体阳性——罕见炎性肌病的不典型表现

doi: 10.12290/xhyxzz.2020-0109
基金项目: 

国家重点研发计划(2018YFC2000300,2018YFC2002100,2018YFC2002104)

详细信息
    通讯作者:

    张宁,电话:010-69154063,E-mail:253571870@qq.com

  • 中图分类号: R685.2

Decreased Muscle Strength, Type 2 Respiratory Failure, Heart Failure, with Positive Anti-mitochondrial Antibodies—Rare Atypical Manifestations of Inflammatory Myopathy

Funds: 

National Key R&D Program of China(2018YFC2000300, 2018YFC2002100, 2018YFC2002104)

  • 摘要: 一例老年女性患者,慢性病程,临床表现为进行性下肢无力、心力衰竭、二氧化碳潴留,伴眶周色素沉着、眉周毳毛增多及多种自身抗体阳性。经多学科团队讨论,以膈肌运动减低引起的限制性通气功能障碍为突破口,逐步梳理病因,结合临床表现、血液学与影像学特征以及股四头肌神经病理实验室肌肉病理与免疫组织化学染色结果,最终诊断为抗线粒体抗体相关炎性肌病。通过纠正心力衰竭、间断无创呼吸机辅助通气及康复训练,患者临床症状及功能状态明显改善。该患者不具有抗线粒体抗体相关炎性肌病的典型表现,能快速明确病因并解决诊疗决策中的难题,再次体现了多学科协作在疑难病诊治中的重大意义。
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出版历程
  • 收稿日期:  2020-12-30
  • 网络出版日期:  2021-06-11

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