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长链非编码RNA与肿瘤干细胞

肖楠 李占峰 姚建新 潘志尧 姚志峰

肖楠, 李占峰, 姚建新, 潘志尧, 姚志峰. 长链非编码RNA与肿瘤干细胞[J]. 协和医学杂志, 2021, 12(3): 373-379. doi: 10.12290/xhyxzz.20190231
引用本文: 肖楠, 李占峰, 姚建新, 潘志尧, 姚志峰. 长链非编码RNA与肿瘤干细胞[J]. 协和医学杂志, 2021, 12(3): 373-379. doi: 10.12290/xhyxzz.20190231
XIAO Nan, LI Zhanfeng, YAO Jianxin, PAN Zhiyao, YAO Zhifeng. Long Non-coding RNA and Cancer Stem Cells[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(3): 373-379. doi: 10.12290/xhyxzz.20190231
Citation: XIAO Nan, LI Zhanfeng, YAO Jianxin, PAN Zhiyao, YAO Zhifeng. Long Non-coding RNA and Cancer Stem Cells[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(3): 373-379. doi: 10.12290/xhyxzz.20190231

长链非编码RNA与肿瘤干细胞

doi: 10.12290/xhyxzz.20190231
详细信息
    通讯作者:

    姚志峰 电话:025-58509711,E-mail:yzf058565@126.com

  • 中图分类号: R73

Long Non-coding RNA and Cancer Stem Cells

More Information
  • 摘要: 肿瘤包含具有干细胞特性的功能细胞亚群,称为肿瘤干细胞(cancer stem cell,CSC),这些细胞亚群在肿瘤的发生和发展中起重要作用。长链非编码RNA(long non-coding RNA,lncRNA)是CSC亚群的关键调节因子,具有诱导CSC自我更新、迁移、侵袭、耐药和分化的重要能力。本文对近年来lncRNA在不同CSC发生、维持和调节中的功能及作用机制进行综述,以期通过lncRNA寻找肿瘤治疗新靶点,以选择性消除CSC,最终改善肿瘤患者的预后。
    作者贡献: 肖楠负责查阅文献、撰写初稿;李占峰、姚建新、潘志尧负责核对文献、提出修改意见;姚志峰负责修订、审核论文。
    利益冲突: 无
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出版历程
  • 收稿日期:  2019-10-22
  • 录用日期:  2020-04-26
  • 刊出日期:  2021-05-30

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