Abstract: Medical research urgently needs to integrate and share a large number of valuable biological samples and data resources to solve difficult problems in major diseases. In medical institutions, the clinical biological sample database plays the role of service-supporting platform for scientific research, which integrates limited biological samples and corresponding data to provide resource guarantee for the exploration of disease occurrence, development, transition, diagnosis, treatment, drug development and health prevention. In this paper, the characteristics and contents of standardized construction of clinical biobank platforms in China, the collaborative management mode of public management platforms, and the operation content and quality control of resource platforms were emphatically expounded. The purpose of this paper is to promote the standardized system construction of platforms of clinical biological sample database in China.