Abstract: Helicobacter pylori is one of the most common pathogenic bacteria of the digestive tract, which is involved in the etiology of acute gastroenteritis, peptic ulcer, gastrointestinal tumor and Parenteral diseases. The epidemiological relationship between Helicobacter pylori and preeclampsia has been confirmed currently. Even tighter association has been found between preeclampsia and infection of cytotoxin-associated gene A (cagA) positive strains of Helicobacter pylori. The anti-caga antibody induced by Helicobacter pylori can have an immune reaction with trophoblast cells, leading to abnormal trophoblast infiltration. In addition, the inflammation and abnormal lipid metabolism caused by Helicobacter pylori can cause abnormal vascular endothelial function, leading to the onset of preeclampsia and the generation of long-term complications. This article reviews the relationship between Helicobacter pylori and preeclampsia and the latest research progress.