Abstract: This article focuses on explicating the core competencies required for clinical and translational medicine mentors from a case scenario. To discuss "how to give a feedback on the evaluation of mentees", first of all, we present problems involved in the case and the connotation of mentorship reflected by the case; after that, each problem is analyzed in depth and solutions are proposed to reflect the core competence of mentors. The core competencies required by a mentorship are skills of communication, management, psychosocial support, career planning, etc.