Abstract: High-quality clinical practice guidelines can effectively guide and regulate clinicians' decision on diagnosis and treatment, improve medical quality, and reduce costs. Since the number of guidelines increases each year and the coverage of guidelines continues to expand, guidelines get more attention from clinicians. It is important for clinicians to know how to understand, develop, and apply clinical guidelines correctly. This article gives a brief introduction of definition, development, and misconception of clinical practice guidelines, and discusses how to quickly evaluate and implement guidelines based on the RIGHT reporting checklist.