Abstract: The discipline of critical care blood purification(CCBP) is a branch of science that aims at studying changes of the internal environment in critically ill patients and relating principles, and exploring the methodology of blood purification with the guidance of theories of critical care medicine. Because of the complexity and variability of the conditions of critically ill patients, we should select different blood purification techniques according to the state of the illness, which makes integration as one of main characteristics of CCBP. There are two forms of integration:sequential integration and concurrent integration. This article will elaborate on the integration feature and main integration techniques of CCBP.