Abstract: Septic acute kidney injury(SAKI) is the leading type of acute kidney injury in critically ill patients. We reviewed currently hot topics including:The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3), big data, precision medicine, novel biomarkers, hemodynamic treatment and critical care blood purification, and deeply explored how to understand those topics correctly, so as to promote the study on SAKI, and apply them into clinical practice properly.