Abstract: Poor tissue perfusion and cellular hypoxia could be persistent even when macro-circulation has been restored, which has become a great challenge for physicians in performing resuscitation on patients with circulatory shock. Hereby, we introduced the concept of resuscitation coherence (RC) to evaluate the interaction of macro-circulatory alteration with the corresponding change of microcirculatory perfusion and cellular oxygen metabolism in resuscitation. Early identification of the loss of RC might be helpful to avoid over-resuscitation and determine the next therapeutic direction.