Abstract: Sepsis is life-threatening multi-organ dysfunction caused by a dysregulated host response to infections, and it is one of the most common and thorny diseases in critically ill patients. With the complement and refinement of sepsis bundles, the mortality rate of sepsis has decreased. However, due to population aging, lifestyle changes, and increasing prevalence of coexisting chronic diseases, its incidence increases significantly, and the pathological process is more complicated, causing the number of annual deaths to rise. Sepsis has become a heavy global burden, which is particularly obvious in poorly resourced settings. The effects of health resource allocation on the epidemic of sepsis, the level of the diagnosis and treatment, and costs of care in sepsis will be discussed in this article. Moreover, it put forward proposals on how to reduce negative effects of poor resource on the occurrence and development of sepsis, and improve compliance of Surviving Sepsis Campaign guidelines.