Abstract: Generalized pustular psoriasis (GPP) is a systemic inflammatory disease with recurrent episodes of erythema, pustules, fever and leukocytosis. Subacute cutaneous lupus erythematosus (SCLE) is an autoimmune disease between discoid lupus erythematosus and systemic lupus erythematosus.Coexistence of the two diseases is uncommon. Here we report a case of generalized pustular psoriasis combined with subacute skin lupus erythematosus. The clinical manifestations and laboratory results are presented and the possible reasons for coexistence are discussed.