Abstract: Pelvic organ prolapse (POP) is a common disease in middle-aged and old women. Both genetic and environmental factors contribute to the development of POP.Predisposing hereditary factor is an important risk factor for POP. The latest progress of genetic research in POP will be discussed in this article. Most studies focused on genes involved in the synthesis and degradation of connective tissue.The genetics of POP remain to be further explored since no definitive conclusions have been reached so far.