Abstract: The development of precision medicine has been the focus of medical field in the world. With the promotion of emerging biotechnology and information technology, pathology is experiencing subject redistribution and reconstruction. With the integratation of organ, tissue, cell, subcellular organelle and molecular complex, and with the combination of radiology, magnetic resonance and ultrasonic imaging, morphomics is established. At the same time, morphomics has established relevance with genomics and other molecular biology to establish connection between morphology and function, and has integrated with environmental, social and human factors to achieve molecular pathologic epidemiology based on large medical data analysis. It is believed that these developments will redefine the bridge role of the pathology in the coming era of precision medicine.