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RSSBcl-2和血管内皮生长因子受体3在子宫静脉内平滑肌瘤病与普通型平滑肌瘤中的表达差异
Different Expressions of Bcl-2 and Vascular Endothelial Growth Factor Receptor-3 in Intravenous Leiomyomatosis and Classical Leiomyoma
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摘要:目的 探索bcl-2和血管内皮生长因子受体3(vascular endothelial growth factor receptor-3, VEGFR-3)在子宫静脉内平滑肌瘤病(intravenous leiomyomatosis, IVL)及普通型平滑肌瘤(leiomyoma, LM)中表达的区别。方法 回顾性分析20例IVL, 并匹配10例LM作为对照, 挑选存档组织块进行bcl-2和VEGFR-3免疫组织化学染色, 分析肿瘤细胞的表达情况并与LM进行对比分析。结果 20例IVL病例bcl-2免疫组织化学染色全部呈中-强着色, 阳性率100%;VEGFR-3免疫组织化学染色19例呈中-强着色, 1例阴性, 阳性率95%。10例LM的bcl-2免疫组织化学染色均呈弱-中等着色, 阳性率100%;而VEGFR-3免疫组织化学染色则均为阴性, 阳性率为0。结论 Bcl-2和VEGFR-3在IVL中均呈高表达, 尤其VEGFR-3表达与LM有明显差异, 提示IVL具有与LM不同的分子改变, 而这些分子改变可能在IVL的发生、发展中起重要作用。Abstract:Objective To explore the different expressions of bcl-2 and vascular endothelial growth factor receptor-3 (VEGFR-3) in intravenous leiomyomatosis (IVL) and classical leiomyoma (LM).Methods We retrospectively reviewed the pathology of 20 cases of IVL, matching with 10 cases of LM. The bcl-2 and VEGFR-3 immunohistochemical staining was performed in the slides from all cases, and the results were compared between the IVL group and LM group.Results In the IVL group, all the 20 cases showed moderate to strong bcl-2 immunohistochemical staining. Meanwhile, 19 cases showed moderate to strong VEGFR-3 immunohistochemical staining, while 1 case was negative. In the LM group, all 10 cases showed weak to moderate bcl-2 immunohistochemical staining and negative VEGFR-3 staining.Conclusions Both bcl-2 and VEGFR-3 are highly expressed in IVL; in particular, the expression of VEGFR-3 is dramatically different between IVL and LM. This indicates IVL and LM have different molecular alterations, which may play important roles in the pathogenesis and development of IVL.
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