邮件订阅 RSS
李文波, 朱庆莉, 姜玉新, 戴晴, 孙健, 张波, 杨萌. 薄层液基细胞学涂片在超声引导下甲状腺细针抽吸活检的应用[J]. 协和医学杂志, 2014, 5(1): 8-12. DOI: 10.3969/j.issn.1674-9081.2014.01.003
引用本文: 李文波, 朱庆莉, 姜玉新, 戴晴, 孙健, 张波, 杨萌. 薄层液基细胞学涂片在超声引导下甲状腺细针抽吸活检的应用[J]. 协和医学杂志, 2014, 5(1): 8-12. DOI: 10.3969/j.issn.1674-9081.2014.01.003
shu
Wen-bo LI, Qing-li ZHU, Yu-xin JIANG, Qing DAI, Jian SUN, Bo ZHANG, Meng YANG. Application of a Thin-layer Liquid-based Technique in Ultrasound-guided Fine Needle Aspiration of Thyroid[J]. Medical Journal of Peking Union Medical College Hospital, 2014, 5(1): 8-12. DOI: 10.3969/j.issn.1674-9081.2014.01.003
Citation: Wen-bo LI, Qing-li ZHU, Yu-xin JIANG, Qing DAI, Jian SUN, Bo ZHANG, Meng YANG. Application of a Thin-layer Liquid-based Technique in Ultrasound-guided Fine Needle Aspiration of Thyroid[J]. Medical Journal of Peking Union Medical College Hospital, 2014, 5(1): 8-12. DOI: 10.3969/j.issn.1674-9081.2014.01.003
shu

薄层液基细胞学涂片在超声引导下甲状腺细针抽吸活检的应用

Application of a Thin-layer Liquid-based Technique in Ultrasound-guided Fine Needle Aspiration of Thyroid

    摘要
  • 摘要:
      目的  探讨薄层液基细胞学涂片技术在超声引导下甲状腺穿刺中的应用价值。
      方法  2008年1月至7月57例患者的57个甲状腺病变进行超声引导下细针抽吸细胞学检查并同时进行薄层液基细胞学涂片。其中14例获得手术病理, 其余病例全部进行临床随访, 随访时间5年至5年6个月。细胞学及组织学诊断结果分为四类:良性、恶性、可疑恶性及涂片不满意, 将其与手术病理及临床随访结果进行对照分析, 分析薄层液基细胞学涂片的细胞学特征及对甲状腺结节的诊断价值。
      结果  薄层液基细胞学涂片与常规细胞学涂片特征有一定差异, 主要表现在背景血细胞明显减少、细胞量较多、集中, 胶质量少或浓集、核较深染、细胞皱缩更常见、常见细胞质碎片及裸核。57个甲状腺病变中, 经手术病理及临床随访证实恶性6个, 良性51个。薄层液基细胞学涂片诊断良性48个(84.2%), 恶性4个(7.0%), 涂片不满意5个(8.8%)。该技术诊断甲状腺恶性结节的敏感性66.7%, 特异性100%, 准确率94.5%, 阳性预测值100%, 阴性预测值96.2%。与常规细胞学涂片诊断结果相似。
      结论  薄层液基细胞学涂片细胞学特征与常规涂片有一定差异, 诊断准确性与常规涂片相似, 在甲状腺结节细针抽吸细胞学检查中有较好的应用价值。

     

    Abstract:
      Objective  To investigate the usefulness of the thin-layer liquid-based cytology in ultrasound-guided fine needle aspiration (UG-FNA) of thyroid gland lesions.
      Methods  From January 2008 to July 2008, 57 thyroid lesions from 57 patients aged from 18 to 78 in Peking Union Medical College Hospital were sampled by ultrasound-guided fine needle aspiration. The cytologic materials were prepared for both conventional and thin-layer liquid-based cytology by PRPSTAIN Processor (Tripath Imaging, BD, USA). All cytological diagnoses were compared with those confirmed by surgical pathology and clinical follow-up. The UG-FNA results were classified as benign, malignant, suspicious, or unsatisfactory. The various cytologic features on liquid-based cyto-logy and conventional preparation were compared.
      Results  Cytomorphologic features showed some differences between the two methods. Liquid-based cytology slides had a clear background and less or dense colloid. It demonstrated more cell shrinkage and showed increased disruption of the cytoplasm and numerous naked nuclei. Among the 57 thyroid lesions, surgical pathology and clinical follow-up confirmed that 6 were malignant and 51 were benign. The thin-layer technology showed that 48 (84.2%) were benign, 4 (7.0%) were malignant, and 5(8.8%)were unsatisfactory for interpretation. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 66.7%, 100%, 94.5%, 100%, and 96.2%, respectively, which were similar with conventional method.
      Conclusions  Liquid-based cytology technique has certain different cellular features when compared with conventional smears but with similar diagnostic accuracy. It is an accurate and reliable method for the preoperative cytological diagnosis of thyroid nodules.

     

    • HTML全文
    • 参考文献(25)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回