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糖皮质激素联合人免疫球蛋白治疗Stevens-Johnson综合征和中毒性表皮松解症

Corticosteroids plus Intravenous Immunoglobulin in the Treatment of 7 Cases with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

    摘要
  • 摘要:
      目的  探讨Stevens-Johnson综合征(Stevens-Johnson syndrome, SJS)和中毒性表皮松解症(toxic epidermal necrolysis, TEN)的临床特征及治疗方法, 以提高对SJS/TEN的认识。
      方法  回顾性分析北京协和医院7例SJS/TEN患者的临床表现、疾病严重程度、眼部受累程度、致敏药物、治疗方案及临床结局。
      结果  患者年龄26~81岁, 均伴有黏膜损害, 致敏药物以非甾体类抗炎药、抗惊厥药及别嘌醇为主, 7例均使用大剂量糖皮质激素联合人免疫球蛋白治疗, 治愈6例, 死亡1例。
      结论  SJS/TEN是一组累及全身皮肤黏膜严重威胁患者生命的疾病, 病死率高, 早期足量使用大剂量糖皮质激素联合人免疫球蛋白为主要的治疗手段, 伴有系统疾病的患者预后较差。眼部损伤与疾病严重程度具有不同步性, 需及早给予针对性治疗。

     

    Abstract:
      Objective  To summarize the clinical features and treatment of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).
      Methods  Seven patients with SJS/TEN were included in the study. The clinical data including severity of illness, eye involvement, causative drugs, treatment, and prognosis were retrospectively analyzed.
      Results  The age of these patients ranged 26 to 81 years. Mucous membranes were affected in all cases. The common agents triggering SJS/TEN in these patients were nonsteroidal anti-inflammatory drugs (NSAIDs), antiepileptic drugs, and allopurinol. All these seven patients were then treated with corticosteroids plus intravenous immunoglobulin (IVIG) for their SJS/TEN. The skin lesions were healed in 6 cases, and 1 death occurred.
      Conclusions  SJS/TEN is a life-threatening exfoliating disease of the skin and mucous membranes, and the mortality can be high without proper treatment. The use of adequate dose of corticosteroids plus IVIG is a main treatment for SJS/TEN, although the prognosis can be poor in patients with systemic diseases. Since ocular involvement in the acute stage may not relate to the severity of SJS/TEN, early ophthalmic assessment and proper treatment is warranted.

     

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