Abstract: Menopause management is a crucial component of promoting healthy aging. However, in an era of information overload, related information is often polarized or even misleading. To address this, the International Menopause Society (IMS) published the latest recommendations and key messages on women’s midlife health and menopause in December 2025. These guidelines aim to provide scientific and standardized clinical guidance for healthcare professionals based on a rigorous evidence retrieval system. The latest guidelines emphasize that healthy lifestyle management serves as the cornerstone, on the basis of which individualized management strategies are developed to maximize benefits and minimize risks. Menopausal hormone therapy remains the most effective intervention. However, a variety of therapeutic options are available in clinical practice, requiring a precision management tailored to individual differences. The latest guidelines also expand on previously underappreciated conditions such as genitourinary syndrome of menopause and sarcopenia, reflecting the growing recognition of comprehensive health management for menopausal women and providing more systematic guidance for clinical practice. This article offers a comprehensive interpretation of the guidelines, aiming to help relevant practitioners keep abreast of international advancements in this field and provide guidance for clinical practice.