跨场强配对MRI脑影像数据集的构建

Construction of a Paired MRI Brain Imaging Dataset Across Field Strengths

  • 摘要: 目的 构建一个包含低场强与高场强配对采集的健康人脑磁共振成像(magnetic resonance imaging,MRI)数据集,为低场强MRI超分辨率(super resolution,SR)重建研究提供重要资源基础。方法 选取2026年1—3月北京邮电大学在读研究生为研究对象,其分别在0.2 T低场强设备和3.0 T高场强设备上接受脑部MRI扫描。低场强采集3个轴位序列:液体衰减反转恢复(fluid-attenuated inversion recovery,FLAIR)、快速自旋回波(fast spin echo,FSE)及多回波自旋回波(multi-spin-echo,MSSE);高场采集各向同性的磁化准备快速梯度回波( magnetization-prepared rapid gradient echo,MPRAGE)和扩散加权成像(diffusion-weighted imaging,DWI)。数据处理流程包括格式转换、体素方向统一、偏置场校正、强度归一化、脑区自动分割,以及MSSE/FSE的双输入超分辨率重建。结果 经筛选后获得76份影像数据,其中10名受试者具备完整的0.2 T / 3.0 T配对数据,另2名受试者仅有0.2 T数据。10名配对受试者的3.0 T结构图像均成功生成包含32个标签的脑区分割图。基于MSSE / FSE生成的SR体积在一定程度上改善了图像质量,10名配对受试者的平均指标为:信噪比为168.470±60.329、对比噪声比为1.729±0.087。结论 本数据集提供了0.2 T与3.0 T同受试者、多序列配对的MRI脑影像资源,可用于低场MRI超分辨率重建模型的训练与评估,也可为跨场强图像质量对比研究提供参考。

     

    Abstract: Objective This study aimed to construct a paired low-field and high-field healthy-brain MRI dataset to provide a valuable resource for low-field MRI super-resolution (SR) research. Methods Post-graduate students enrolled at Beijing University of Posts and Telecommunications from January to March 2026 were recruited and underwent brain MRI scans on both a 0.2 T low-field scanner and a 3.0 T high-field scanner. The low-field protocol comprised three axial sequences—fluid-attenuated inversion recovery (FLAIR),fast spin echo (FSE),and multi-spin-echo (MSSE). The high-field protocol included a magnetization-prepared rapid gradient echo (MPRAGE) sequence with isotropic resolution,as well as diffusion-weighted imaging (DWI).Post-acquisition processing included format conversion,orientation unification,bias-field correction,intensity normalization,automated brain parcellation,and SynthSR-hyperfine SR reconstruction using paired 0.2T MSSE/FSE inputs. Results After quality control and selection,a total of 76 imaging volumes were obtained,including complete 0.2 T/3.0 T paired data for 10 subjects and 0.2 T-only data for 2 additional subjects. 32-label brain parcellations were successfully generated for all 10 paired subjects. SR volumes generated from MSSE/FSE pairs showed a certain level of improvement in image quality. Across the 10 paired subjects,mean metrics were: SNR 168.470±60.329,CNR 1.729±0.087. Conclusions This dataset provides a multi-sequence paired brain MRI resource at 0.2 T and 3.0 T. It can serve as a benchmark for training and evaluating low-field MRI super-resolution models and for cross-field-strength image quality studies.

     

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